Hypertension:睡眠限制对健康年轻人动态和睡眠期间血压的影响

2021-07-16 MedSci原创 MedSci原创

睡眠时间缩短会导致24小时血压和睡眠时间血压持续升高。尽管严格控制食物摄入量和体重,但升压效应仍然很明显,这表明它们主要是由睡眠时间缩短所致。

尽管睡眠不足与血管风险增加有关,但缺乏因果关系的证据。

近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员分析了长期睡眠限制对20名健康年轻参与者(年龄为23.4±4.8岁,9名女性)24小时动态血压(BP)和其他心血管指标的影响。

这些参与者接受了为期16天的随机、对照、交叉住院研究,包括4天的适应期、9天的睡眠限制(每晚睡眠4小时)或对照睡眠(每晚睡眠9小时)和3天的恢复期。受试者自始至终食用搭营养成分搭配好饮食进行体重维持。研究人员重复测量了受试者24小时血压(主要结局)和心血管生物标志物,并接受连续的多导睡眠监测。

研究人员将睡眠限制与对照睡眠进行比较发现,24小时平均血压更高(第12天调整后平均差:2.1 mmHg[95%CI为0.6-3.6],校正P=0.016),内皮功能减弱(P<0.001)和血浆去甲肾上腺素升高(P=0.011)。尽管深度睡眠增加,但在睡眠限制期和恢复期间血压升高。事后分析发现仅在睡眠限制的女性受试者实验阶段和恢复阶段,24小时血压、觉醒和睡眠血压升高,其中24小时血压和睡眠收缩压分别升高8.0(5.1-10.8)和11.3(5.9-16.7)mmHg(均P<0.001)。

由此可见,睡眠时间缩短会导致24小时血压和睡眠时间血压持续升高。尽管严格控制食物摄入量和体重,但升压效应仍然很明显,这表明它们主要是由睡眠时间缩短所致。女性的血压升高尤其显著且持续,这表明对睡眠不足缺乏适应性,因此更容易受到其不良心血管效应的影响。

原始出处:

Naima Covassin.et al.Effects of Experimental Sleep Restriction on Ambulatory and Sleep Blood Pressure in Healthy Young Adults: A Randomized Crossover Study.Hypertension.2021.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.121.17622

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    2022-05-18 feather89
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    2021-07-16 tanxingdoctor

    学习啦

    0

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    2021-07-16 ms2658711348342440

    良好的睡眠多么重要

    0

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