J Rheumatol:银屑病关节炎、银屑病、类风湿性关节炎和强直性脊柱炎的危险因素

2021-09-01 xiangting MedSci原创

这四种疾病既有共同危险因素,也有不同的危险因素,使用他汀类药物与这4种疾病呈负相关。

近日一项发表在风湿病学权威期刊J Rheumatol上的研究比较银屑病关节炎(PsA)、银屑病、类风湿性关节炎(RA)和强直性脊柱炎(AS)的潜在危险因素。

                             

研究使用健康改善网络1994 年至 2015 年的数据进行了4项平行病例对照研究。 使用疾病编码查找PsA、银屑病、RA 或 AS 患者,并与年龄、性别和治疗年份匹配的对照配对。使用自动逐步回归为每种疾病构建多因素 logistic 回归模型以分析潜在危险因素。

纳入PsA (N=7,594)、银屑病 (N=111,375)、RA (N=28,341) 和 AS (N=3,253) 患者,并分别与75930、1113345、282226 和 32530名对照匹配。中位诊断年龄分别为 48(IQR 38-59)、41(31-54)、43(31-54) 和 60 (48-71)。在多因素模型中,这四种疾病有共同危险因素,也有不同的危险因素:PsA 与肥胖、咽炎和皮肤感染相关;PsA 和银屑病与肥胖和中度饮酒相关;PsA 和 AS 与葡萄膜炎相关;PsA 和 RA 与既往痛风相关。RA 和 AS 均与目前吸烟、既往饮酒、贫血、骨质疏松和炎症性肠病相关。既往吸烟或目前吸烟是这4种疾病的共有危险因素;使用他汀类药物与这4种疾病呈负相关。

                                         四种疾病的危险因素

由此可见,这项研究确定了PsA、银屑病、RA 和 AS 的危险因素。使用他汀类药物与这4种疾病呈负相关。

 

原始出处:

Elana Meer. Risk factors for diagnosis of psoriatic arthritis, psoriasis, rheumatoid arthritis, and ankylosing spondylitis: A set of parallel case-control studies. J Rheumatol. September 2021.

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    2022-07-10 屋顶瞄爱赏月

    签到学习

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    2022-06-17 zywlvao
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    2021-09-03 lmm397
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