Clin Exp Allergy:过敏性疾病与心理健康存在因果关系吗?

2021-10-16 MedSci原创 MedSci原创

与表型关联相比,研究人员发现任何因果效应都大大减弱。这表明临床观察到的大多数合并症不太可能存在因果关系。

观察性研究报告了过敏性疾病与心理健康之间的关联,但尚未确定因果关系。

近日,过敏性疾病领域权威杂志Clinical and Experimental Allergy上发表了一篇研究文章,研究人员使用孟德尔随机化(MR)来探究过敏性疾病与心理健康表型之间可能的因果关系。

英国生物银行调查了过敏性疾病与心理健康之间的观察关系。研究人员使用来自已发表的全基因组关联研究的汇总数据,通过双向两样本MR探究因果关系的方向。遗传工具源自广泛过敏性疾病表型之间的相关变异,以评估与各种心理健康结局之间的因果关系。研究人员还调查了这些关联是否特定于特应性皮炎(AD)、哮喘或花粉症。鉴于多重检验负担,研究人员应用Bonferroni校正以使用0.0016的单个检验p值阈值(32次检验)。

研究人员发现了广泛过敏性疾病表型与抑郁症(OR=1.45,95%CI为1.41-1.50,p=3.6×10−130)、焦虑(OR=1.25,95%CI为1.18-1.33,p=6.5×10−13)、双相情感障碍(OR=1.29,95%CI为1.12-1.47,p=2.8×10−4)和神经质(β=0.38,95%CI为0.36-0.41,p=6.8×10−166)相关。在哮喘、AD、花粉症与心理健康表型之间也发现了类似的关联,尽管AD和花粉症与双相情感障碍之间的关联较弱。在任一方向上几乎没有发现因果关系的证据(所有p值>0.02)。

由此可见,使用MR,并未重复出过敏性疾病与心理健康之间大多数表型的关联。与表型关联相比,研究人员发现任何因果效应都大大减弱。这表明临床观察到的大多数合并症不太可能存在因果关系。

原始出处:  

Ashley Budu-Aggrey.et al.Investigating the causal relationship between allergic disease and mental health.Clin Exp Allergy. 2021.https://onlinelibrary.wiley.com/doi/10.1111/cea.14010

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2047450, encodeId=085c204e450da, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Tue Mar 01 16:34:43 CST 2022, time=2022-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329567, encodeId=7990132956e77, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Oct 18 02:34:43 CST 2021, time=2021-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061028, encodeId=966710610282e, content=<a href='/topic/show?id=b2f994044aa' target=_blank style='color:#2F92EE;'>#过敏性疾病#</a>与<a href='/topic/show?id=7f3f5111924' target=_blank style='color:#2F92EE;'>#心理健康#</a>,肯定有关的,甚至二者是相互作用的!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94044, encryptionId=b2f994044aa, topicName=过敏性疾病), TopicDto(id=51119, encryptionId=7f3f5111924, topicName=心理健康)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sat Oct 16 14:01:52 CST 2021, time=2021-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061009, encodeId=55ff10610097c, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Sat Oct 16 12:10:37 CST 2021, time=2021-10-16, status=1, ipAttribution=)]
    2021-10-18 膀胱癌
  3. [GetPortalCommentsPageByObjectIdResponse(id=2047450, encodeId=085c204e450da, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Tue Mar 01 16:34:43 CST 2022, time=2022-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329567, encodeId=7990132956e77, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Oct 18 02:34:43 CST 2021, time=2021-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061028, encodeId=966710610282e, content=<a href='/topic/show?id=b2f994044aa' target=_blank style='color:#2F92EE;'>#过敏性疾病#</a>与<a href='/topic/show?id=7f3f5111924' target=_blank style='color:#2F92EE;'>#心理健康#</a>,肯定有关的,甚至二者是相互作用的!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94044, encryptionId=b2f994044aa, topicName=过敏性疾病), TopicDto(id=51119, encryptionId=7f3f5111924, topicName=心理健康)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sat Oct 16 14:01:52 CST 2021, time=2021-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061009, encodeId=55ff10610097c, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Sat Oct 16 12:10:37 CST 2021, time=2021-10-16, status=1, ipAttribution=)]
    2021-10-16 病毒猎手

    #过敏性疾病##心理健康#,肯定有关的,甚至二者是相互作用的!!

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2047450, encodeId=085c204e450da, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Tue Mar 01 16:34:43 CST 2022, time=2022-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329567, encodeId=7990132956e77, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Oct 18 02:34:43 CST 2021, time=2021-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061028, encodeId=966710610282e, content=<a href='/topic/show?id=b2f994044aa' target=_blank style='color:#2F92EE;'>#过敏性疾病#</a>与<a href='/topic/show?id=7f3f5111924' target=_blank style='color:#2F92EE;'>#心理健康#</a>,肯定有关的,甚至二者是相互作用的!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94044, encryptionId=b2f994044aa, topicName=过敏性疾病), TopicDto(id=51119, encryptionId=7f3f5111924, topicName=心理健康)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sat Oct 16 14:01:52 CST 2021, time=2021-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061009, encodeId=55ff10610097c, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Sat Oct 16 12:10:37 CST 2021, time=2021-10-16, status=1, ipAttribution=)]
    2021-10-16 yangchou

    好文章,谢谢分享。

    0

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