妊娠期母体饮食与儿童呼吸道健康-来自18000名儿童个体病例数据meta分析

2021-09-15 小文子 MedSci原创

妊娠期间母体饮食与儿童期呼吸系统结局之间是否存在相关性?

严重胎儿营养不良与日后患呼吸系统疾病的风险增加有关,但是,妊娠期间母体饮食与儿童期呼吸系统结局之间是否存在相关性?近日,发表在European Respiratory Journal的一篇文章探索孕妇妊娠期间的促炎性饮食和低质量饮食是否与儿童呼吸道健康有关。

研究人员对7个欧洲出生队列的18326对母子进行个体病例数据meta分析,研究通过能量校正饮食炎症指数(E-DII)和阻止高血压的饮食方案(DASH)评分对孕妇的饮食炎症指数和质量进行评估。采用问卷调查法测定婴幼儿喘息和学龄期哮喘,采用肺量测定法测定肺功能。

妊娠期间母体E-DII 评分较高(饮食炎症指数较高)仅与儿童用力肺活量FVC 较低有关(Z = -0.05, 95%CI [- 0.08, -0.02])。母体E-DII 或 DASH 评分与儿童喘息和哮喘并不存在线性关系。极低DASH 评分 (<10百分位数)(饮食质量非常低)与学龄前喘息风险增加和第一秒用力呼气末容积与用力肺活量的比值(FEV1/FVC)较低相关(Z < -1.64; OR=1.20, 95%CI [1.06, 1.36]; OR=1.40, 95%CI [1.06, 1.85]),相应的人群归因风险度分别为1.7% 3.3%

个体病例数据meta分析结果表明,妊娠期母体促炎性饮食和低质量饮食与儿童呼吸系统疾病无相关性

原文出处:

Sara M. Mensink-BoutEvelien R.Maternal diet in pregnancy and child's respiratory outcomes: an individual participant data meta-analysis of 18 000 children, European Respiratory Journal 2021, https://doi.org/10.1183/13993003.01315-2021

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    2021-12-22 guojianrong
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    2022-05-03 一闲
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    2021-09-16 wjcjjian
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    2021-09-16 zhmscau

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