Faces at different angles

Black voices in cancer research and oncology

Kilan C. Ashad-Bishop, Onyinye D. Balogun, Runcie C.W. Chidebe, Leah M. Cook & Christina Towers  

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  • two people representing an early-career researcher and their mentor

    Nature Reviews Cancer is committed to facilitating training in peer review and to ensuring that everyone involved in our peer-review process is recognised. We have therefore joined an initiative to allow and encourage established referees to involve one early-career researcher in our peer-review process.

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    These Milestones celebrate two decades of breakthroughs in basic, translational and clinical research which have revolutionized our understanding and management of cancer.

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  • In this World View, H. Michael Shepard describes his personal story behind the discovery of trastuzumab, 25 years since its FDA approval for HER2-overexpressing breast cancers.

    • H. Michael Shepard
    World View
  • Fu et al. provide data indicating a pathogenic role for Streptococcus anginosus in gastric cancer.

    • Anna Dart
    Research Highlight
  • Recently published in Nature, Fan et al. demonstrate that accumulation of advanced glycation end-products in the extracellular matrix of the liver increases viscoelasticity to promote hepatocellular carcinoma growth, independent of stiffness.

    • Gabrielle Brewer
    Research Highlight
  • Two independent studies published in Nature implicate distal cholesterol biosynthesis in the regulation of ferroptosis and show that 7-dehydrocholesterol (7-DHC) is an endogenous, anti-ferroptotic metabolite.

    • Daniela Senft
    Research Highlight
  • In this Tools of the Trade, Juliann Shih describes the development of BISCUT, which detects genomic loci that are subject to fitness advantages or disadvantages by interrogating the length distributions of partial somatic copy-number alterations to enable the discovery of new drivers of aneuploidy in cancer.

    • Juliann Shih
    Tools of the Trade
  • Mutant gain-of-function p53 is commonly found in human cancers. Huang, Cao, Qian et al. developed and validated the use of multifunctional biomimetic nanoreceptors that bind to and promote the degradation of mutant p53 as a cancer therapy.

    • Gabrielle Brewer
    Research Highlight
Six human body silhouettes, the three on the left are male-shaped, the three on the right female.

Sex differences in cancer

Sex differences begin at fertilization and affect nearly all body systems during development.
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