Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Yamaoka, T; Ohba, M; Arata, S; Ohmori, T

Yamaoka, T (reprint author), Showa Univ, Inst Mol Oncol, Tokyo, Japan.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2017; (126):

Abstract

Drug resistance is a major challenge in cancer therapy. The generation of resistant sublines in vitro is necessary for discovering novel mechanisms to......

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