A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance

Schmidt, TT; Sharma, S; Reyes, GX; Gries, K; Gross, M; Zhao, BY; Yuan, JH; Wade, R; Chabes, A; Hombauer, H

Hombauer, H (reprint author), German Canc Res Ctr, DNA Repair Mech & Canc, D-69120 Heidelberg, Germany.

NUCLEIC ACIDS RESEARCH, 2019; 47 (1): 237

Abstract

The balance and the overall concentration of intracellular deoxyribonucleoside triphosphates (dNTPs) are important determinants of faithful DNA replic......

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