Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

Brennan, MS; Chang, C; Tai, L; Lessene, G; Strasser, A; Dewson, G; Kelly, GL; Herold, MJ

Herold, MJ (reprint author), Walter & Eliza Hall Inst Med Res, 1G Royal Parade, Parkville, Vic 3052, Australia.

BLOOD, 2018; 132 (15): 1573

Abstract

Myeloid cell leukemia-1 (MCL-1) is a prosurvival B-cell lymphoma 2 (BCL-2) family member required for the sustained growth of many cancers. Recently, ......

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