Nanocrystals of a new camptothecin derivative WCN-21 enhance its solubility and efficacy

You, J; Chen, YY; Alsayeh, ZMM; Shen, XY; Li, C; Zhao, PX; Chen, F; Liu, YQ; Xu, CR

Xu, CR (reprint author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Wuhan 430030, Peoples R China.; Liu, YQ (reprint author), Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China.

ONCOTARGET, 2017; 8 (18): 29808

Abstract

WCN-21 is a new camptothecin derivative we synthesized and has desirable anti-tumor efficacy, but its aqueous solubility is very low and hurdles the f......

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