De novo dNTP production is essential for normal postnatal murine heart development

Tran, P; Wanrooij, PH; Lorenzon, P; Sharma, S; Thelander, L; Nilsson, AK; Olofsson, AK; Medini, P; von Hofsten, J; Stal, P; Chabes, A

Chabes, A (reprint author), Umea Univ, Dept Med Biochem & Biophys, S-90187 Umea, Sweden.; Chabes, A (reprint author), Umea Univ, Lab Mol Infect Med Sweden MIMS, S-90187 Umea, Sweden.

JOURNAL OF BIOLOGICAL CHEMISTRY, 2019; 294 (44): 15889

Abstract

The building blocks of DNA, dNTPs, can be produced de novo or can be salvaged from deoxyribonucleosides. However, to what extent the absence of de nov......

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