笔记详情
标题
Discovery of early urinary biomarkers in preclinical study
内容
Drug-induced nephrotoxicity accounts for up to 25 % of
the organ toxicity noted in preclinical studies during drug
development (Bennett et al. 1988). Extensive exposure to
high concentrations of xenobiotic compounds and their
active metabolites can have a major pathological effect onthe kidney (Werner et al. 1995). Currently, elevated blood
urea nitrogen (BUN) and serum creatinine (sCRE) are the
most common clinical indicators of renal injury, however,
sCRE concentrations may not be altered until a significant
amount of kidney function is lost (Price 1992; Duarte and
Preuss 1993). The low sensitivity of the current clinical
markers limits the detection of early stages of renal damage,
affecting patient care and increasing total medical
costs. Therefore, the discovery of novel, sensitive and
noninvasive biomarkers of acute kidney injury is of great
interest, especially those which can differentiate between
development of and recovery from injury. 点击翻译
the organ toxicity noted in preclinical studies during drug
development (Bennett et al. 1988). Extensive exposure to
high concentrations of xenobiotic compounds and their
active metabolites can have a major pathological effect onthe kidney (Werner et al. 1995). Currently, elevated blood
urea nitrogen (BUN) and serum creatinine (sCRE) are the
most common clinical indicators of renal injury, however,
sCRE concentrations may not be altered until a significant
amount of kidney function is lost (Price 1992; Duarte and
Preuss 1993). The low sensitivity of the current clinical
markers limits the detection of early stages of renal damage,
affecting patient care and increasing total medical
costs. Therefore, the discovery of novel, sensitive and
noninvasive biomarkers of acute kidney injury is of great
interest, especially those which can differentiate between
development of and recovery from injury. 点击翻译
来源
http://link.springer.com/article/10.1007/s11306-012-0423-7
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