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Increased Wheat Protein Content via Introgression of an HMW Glutenin Selectively Reshapes the Grain Proteome

期刊: MOLECULAR & CELLULAR PROTEOMICS, 2021; 20 ()

Introgression of a high-molecular-weight glutenin subunit (HMW-GS) allele, 1Ay21*, into commercial wheat cultivars increased overall grain protein con......

Adipose Triglyceride Lipase Loss Promotes a Metabolic Switch in A549 Non-Small Cell Lung Cancer Cell Spheroids

期刊: MOLECULAR & CELLULAR PROTEOMICS, 2021; 20 ()

Cancer cells undergo complex metabolic adaptations to survive and thrive in challenging environments. This is particularly prominent for solid tumors,......

Transcriptome and Secretome Analysis of Intra-Mammalian Life-Stages of Calicophoron daubneyi Reveals Adaptation to a Unique Host Environment

期刊: MOLECULAR & CELLULAR PROTEOMICS, 2021; 20 ()

Paramphistomosis, caused by the rumen fluke, Calicophoron daubneyi, is a parasitic infection of ruminant livestock, which has seen a rapid rise in pre......

Antibody Binding Epitope Mapping (AbMap) of Hundred Antibodies in a Single Run

期刊: MOLECULAR & CELLULAR PROTEOMICS, 2021; 20 ()

Antibodies play essential roles in both diagnostics and therapeutics. Epitope mapping is essential to understand how an antibody works and to protect ......

Secretome and Comparative Proteomics of Yersinia pestis Identify Two Novel E3 Ubiquitin Ligases That Contribute to Plague Virulence

期刊: MOLECULAR & CELLULAR PROTEOMICS, 2021; 20 ()

Plague is a zoonotic disease that primarily infects rodents via fleabite. Transmission from flea to host niches requires rapid adaption of Yersinia pe......

Mapping Isoform Abundance and Interactome of the Endogenous TMPRSS2-ERG Fusion Protein by Orthogonal Immunoprecipitation-Mass Spectrometry Assays

期刊: MOLECULAR & CELLULAR PROTEOMICS, 2021; 20 ()

TMPRSS2-ERG gene fusion, a molecular alteration found in nearly half of primary prostate cancer cases, has been intensively characterized at the trans......

Proteogenomic Characterization of the Pathogenic Fungus Aspergillus flavus Reveals Novel Genes Involved in Aflatoxin Production

期刊: MOLECULAR & CELLULAR PROTEOMICS, 2021; 20 ()

Aspergillus flavus (A. flavus), a pathogenic fungus, can produce carcinogenic and toxic aflatoxins that are a serious agricultural and medical threat ......

Recent Advances in Software Tools for More Generic and Precise Intact Glycopeptide Analysis

期刊: MOLECULAR & CELLULAR PROTEOMICS, 2021; 20 ()

Intact glycopeptide identification has long been known as a key and challenging barrier to the comprehensive and accurate understanding the role of gl......

Quantitative Proteomics Reveals Association of Neuron Projection Development Genes ARF4, KIF5B, and RAB8A With Hirschsprung Disease

期刊: MOLECULAR & CELLULAR PROTEOMICS, 2021; 20 ()

Hirschsprung disease (HSCR) is a heterogeneous group of neurocristopathy characterized by the absence of the enteric ganglia along a variable length o......

Proteomic Profiling of Gastric Signet Ring Cell Carcinoma Tissues Reveals Characteristic Changes of the Complement Cascade Pathway

期刊: MOLECULAR & CELLULAR PROTEOMICS, 2021; 20 ()

Signet ring cell carcinoma (SRCC) is a histological subtype of gastric cancer with distinct features in multiple aspects compared with adenocarcinomas......

Age-Associated Proteomic Signatures and Potential Clinically Actionable Targets of Colorectal Cancer

期刊: MOLECULAR & CELLULAR PROTEOMICS, 2021; 20 ()

The occurrence and prevalence of colorectal cancer (CRC) is closely associated with age. More than 90% of patients with CRC are diagnosed after 50 yea......

Global Lysine Acetylation and 2-Hydroxyisobutyrylation Profiling Reveals the Metabolism Conversion Mechanism in Giardia lamblia

期刊: MOLECULAR & CELLULAR PROTEOMICS, 2021; 20 ()

Giardia lamblia (G. lamblia) is the cause of giardiasis, a common infection that affects the general population of the world. Despite the constant pos......

Prediction and Validation of Mouse Meiosis-Essential Genes Based on Spermatogenesis Proteome Dynamics

期刊: MOLECULAR & CELLULAR PROTEOMICS, 2021; 20 ()

The molecular mechanism associated with mammalian meiosis has yet to be fully explored, and one of the main reasons for this lack of exploration is th......

A Potential Role for the Gsdf-eEF1 alpha Complex in Inhibiting Germ Cell Proliferation: A Protein-Interaction Analysis in Medaka (Oryzias latipes) From a Proteomics Perspective

期刊: MOLECULAR & CELLULAR PROTEOMICS, 2021; 20 ()

Gonadal soma-derived factor (gsdf) has been demonstrated to be essential for testicular differentiation in medaka (Oryzias latipes). To understand the......

Protein Modification Characteristics of the Malaria Parasite Plasmodium falciparum and the Infected Erythrocytes

期刊: MOLECULAR & CELLULAR PROTEOMICS, 2021; 20 ()

Malaria elimination is still pending on the development of novel tools that rely on a deep understanding of parasite biology. Proteins of all living c......

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