期刊： TOXICOLOGICAL SCIENCES, 2021; 180 (2)
Lead (Pb) is a highly toxic heavy metal that broadly exists in our living environment. Although Pb has been shown to influence the development of immu......
期刊： TOXICOLOGICAL SCIENCES, 2021; 181 (2)
The idiosyncratic characteristics and severity of acetaminophen (APAP) overdose-induced hepatotoxicity render identifying the predisposing factors and......
期刊： TOXICOLOGICAL SCIENCES, 2021; 181 (2)
Cholestasis is one of the most severe manifestations of liver injury and has limited therapeutic options. Allopurinol (AP), an inhibitor of uric acid ......
期刊： TOXICOLOGICAL SCIENCES, 2021; 182 (2)
Endemic fluorosis is caused by the intake of high environmental fluoride, which causes dental and skeletal fluorosis. Osteoblast proliferation and act......
期刊： TOXICOLOGICAL SCIENCES, 2021; 179 (2)
Circular RNAs (circRNAs) are a type of closed, long, non-coding RNAs, which have attracted significant attention in recent years. CircRNAs exhibit uni......
期刊： TOXICOLOGICAL SCIENCES, 2021; 179 (1)
One of the most carcinogenic chemicals found in cigarette tobacco smoke is 4-(methylnitrosamino)-1-(3-pyridyl)-1butanone (NNK), which has been confirm......
期刊： TOXICOLOGICAL SCIENCES, 2021; 179 (1)
Microcystin-LR (MC-LR), the most common and toxic microcystin (MC) present in freshwater, poses a substantial threat to human health, especially hepat......
期刊： TOXICOLOGICAL SCIENCES, 2020; 177 (1)
Sox9 has been previously characterized as a transcription factor responsible for the extracellular matrix production during liver fibrosis. However, t......
期刊： TOXICOLOGICAL SCIENCES, 2020; 177 (1)
Excess cobalt may lead to metallosis, characterized by sensorineural hearing loss, visual, and cognitive impairment, and peripheral neuropathy. In the......
期刊： TOXICOLOGICAL SCIENCES, 2020; 177 (1)
Inorganic arsenic (iAs) is a recognized environment-related factor for bladder cancer (BCa). Arsenic (+3 oxidation state) methyltransferase (AS3MT) ge......
期刊： TOXICOLOGICAL SCIENCES, 2020; 177 (2)
PCB118, a 2,3',4,4',5-pentachlorobiphenyl, has been shown to destroy thyroidal ultrastructure and induce thyrocyte autophagy. Previously, we reported ......
期刊： TOXICOLOGICAL SCIENCES, 2020; 177 (2)
Studies have shown that mammalian testes, in particular the Sertoli cells, are highly susceptible to exposure of environmental toxicants, such as cadm......
期刊： TOXICOLOGICAL SCIENCES, 2020; 178 (2)
Congenital heart disease (CHD), the leading birth defect worldwide, has a largely unknown etiology, likely to result from complex interactions between......
期刊： TOXICOLOGICAL SCIENCES, 2020; 178 (1)
Bisphenols are endocrine disrupting chemicals to which humans are ubiquitously exposed to. Prenatal bisphenol A exposure can lead to insulin resistanc......
期刊： TOXICOLOGICAL SCIENCES, 2020; 178 (1)
Paraquat (PQ) is herbicide widely used in agricultural production. It is identified as an environmental toxicant that could lead to neurodegeneration ......
