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IL-17 is a potential biomarker for predicting the severity and outcomes of pulmonary contusion in trauma patients

期刊: BIOMEDICAL REPORTS, 2021; 14 (1)

Pulmonary contusion (PC) is very common in blunt chest trauma, and always results in negative pulmonary outcomes, such as pneumonia, acute respiratory......

Identification of novel variants in the LDLR gene in Russian patients with familial hypercholesterolemia using targeted sequencing

期刊: BIOMEDICAL REPORTS, 2021; 14 (1)

Familial hypercholesterolemia (FH) is caused by mutations in various genes, including the LDLR, APOB and PSCK9 genes; however, the spectrum of these m......

lncRNA HIF1A-AS2: A potential oncogene in human cancers (Review)

期刊: BIOMEDICAL REPORTS, 2021; 15 (4)

Long non-coding RNAs (lncRNAs) are transcripts that are >200 nucleotides, but with no open reading frame. An increasing number of lncRNAs have been......

Autophagy controls programmed death-ligand 1 expression on cancer cells (Review)

期刊: BIOMEDICAL REPORTS, 2021; 15 (4)

Programmed death-ligand 1 (PD-L1) is a transmembrane protein mainly located on cancer cells, including renal cell carcinoma, breast, colorectal, gastr......

Regulation of gene transcription of B lymphoma Mo-MLV insertion region 1 homolog (Review)

期刊: BIOMEDICAL REPORTS, 2021; 14 (6)

B lymphoma Mo-MLV insertion region 1 homolog (Bmi-1) is a core protein component of the polycomb repressive complex 1 that inhibits cell senescence an......

Ginaton injection alleviates cisplatin-induced renal interstitial fibrosis in rats via inhibition of apoptosis through regulation of the p38MAPK/TGF-beta 1 and p38MAPK/HIF-1 alpha pathways

期刊: BIOMEDICAL REPORTS, 2021; 14 (4)

Ginaton injection (Ginkgo biloba extract; GBE) has been reported to protect against cisplatin-induced acute renal failure in rats. In the present stud......

Tripterygium wilfordii derivative LLDT-8 targets CD2 in the treatment of rheumatoid arthritis

期刊: BIOMEDICAL REPORTS, 2021; 15 (4)

Rheumatoid arthritis (RA), a chronic inflammatory synovitis systemic disease, can lead to joint deformities, loss of function and even death. The path......

Functions of CD169 positive macrophages in human diseases (Review)

期刊: BIOMEDICAL REPORTS, 2021; 14 (2)

CD169(+) macrophages are a unique type of macrophage subset that differ from M1 and M2 macrophages. CD169(+) macrophages are present in multiple tissu......

Flare-up of cytokines in rheumatoid arthritis and their role in triggering depression: Shared common function and their possible applications in treatment (Review)

期刊: BIOMEDICAL REPORTS, 2021; 14 (1)

Chronic illnesses are associated with an increased risk of depression and anxiety. Rheumatoid arthritis (RA) is a chronic autoimmune disease that typi......

Effect of oxymatrine on liver gluconeogenesis is associated with the regulation of PEPCK and G6Pase expression and AKT phosphorylation

期刊: BIOMEDICAL REPORTS, 2021; 15 (1)

An increase in liver gluconeogenesis is an important pathological phenomenon in type 2 diabetes mellitus (T2DM) and oxymatrine is an effective natural......

Time course of histopathological changes after bleomycin sclerotherapy in rabbit gallbladders as a model for simple hepatic cysts

期刊: BIOMEDICAL REPORTS, 2021; 15 (3)

Bleomycin sclerotherapy is used in the treatment of cystic lesions; however, the histopathological changes are undefined. Present animal models of cys......

Differences in the reaction of hyperlipidemia on different endothelial progenitor cells based on sex

期刊: BIOMEDICAL REPORTS, 2021; 15 (2)

The sex of a patient can affect the outcomes of several cardiovascular diseases, and men generally tend to experience earlier episodes of cardiovascul......

Role of endothelial-microparticles and the tissue factor pathway in ginsenoside Rb1-mediated prevention of umbilical vein endothelial cell injury

期刊: BIOMEDICAL REPORTS, 2021; 14 (1)

Hepatic veno-occlusive disease (VOD) is a life-threatening complication of hematopoietic stem cell transplantation, which urgently requires effective ......

Associations of the MTHFR rs1801133 polymorphism with gastric cancer risk in the Chinese Han population

期刊: BIOMEDICAL REPORTS, 2021; 14 (1)

In recent years, increasing evidence has implicated the importance of mutations in the MTHFR gene in the risk of gastric cancer risk. A single nucleot......

Elevated levels of serum IL-36 alpha in patients with systemic lupus erythematosus

期刊: BIOMEDICAL REPORTS, 2021; 15 (3)

The present study aimed to investigate the levels of IL-36 alpha and its association with disease activity in patients with systemic lupus erythematos......

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