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Daratumumab provides a survival benefit in relapsed and refractory Multiple Myeloma, independent of baseline clinical characteristics: A meta-analysis

期刊: PHARMACOLOGY RESEARCH & PERSPECTIVES, 2021; 9 (4)

Daratumumab was approved in patients with relapsed or refractory multiple myeloma (MM) who previously received proteasome inhibitors or immunomodulato......

Dexamethasone promotes the endoplasmic reticulum stress response of bone marrow mesenchymal stem cells by activating the PERK-Nrf2 signaling pathway

期刊: PHARMACOLOGY RESEARCH & PERSPECTIVES, 2021; 9 (3)

The pathogenesis of steroid-induced avascular necrosis of femoral head (SANFH) is complex, and there is a lack of effective early prevention method. T......

A meta-analysis and cost-minimization analysis of bivalirudin versus heparin in high-risk patients for percutaneous coronary intervention

期刊: PHARMACOLOGY RESEARCH & PERSPECTIVES, 2021; 9 (3)

This meta-analysis was performed to compare the safety, efficacy, and pharmacoeconomic of bivalirudin versus heparin in high-risk patients for percuta......

Side-effects of carbetocin to prevent postpartum hemorrhage: A systematic review and meta-analysis of randomized controlled trials

期刊: PHARMACOLOGY RESEARCH & PERSPECTIVES, 2021; 9 (2)

Postpartum hemorrhage (PPH) increases the risk of maternal death worldwide. Heat-stable carbetocin, a long-acting oxytocin analog, is a newer uteroton......

Nobiletin ameliorates cardiac impairment and alleviates cardiac remodeling after acute myocardial infarction in rats via JNK regulation

期刊: PHARMACOLOGY RESEARCH & PERSPECTIVES, 2021; 9 (2)

Nobiletin was found to protect against acute myocardial infarction (AMI)-induced cardiac function decline and myocardial remodeling, although the dose......

Mouse strain specificity of DAAO inhibitors-mediated antinociception

期刊: PHARMACOLOGY RESEARCH & PERSPECTIVES, 2021; 9 (2)

D-Amino acid oxidase (DAAO) specifically catalyzes the oxidative deamination of neutral and polar D-amino acids and finally yields byproducts of hydro......

Circ_0001821 knockdown suppresses growth, metastasis, and TAX resistance of non-small-cell lung cancer cells by regulating the miR-526b-5p/GRK5 axis

期刊: PHARMACOLOGY RESEARCH & PERSPECTIVES, 2021; 9 (4)

Non-small-cell lung cancer (NSCLC) remains a huge obstacle to human health. Certain circular RNAs endow with crucial regulatory roles in NSCLC progres......

Changes in clinical trials of endocrine disorder and metabolism and nutrition disorder drugs in mainland China over 2010-2019

期刊: PHARMACOLOGY RESEARCH & PERSPECTIVES, 2021; 9 (2)

With the improvements in relevant policies, laws, and regulations regarding drug clinical trials in China, the quantity and quality of drug clinical t......

The therapeutic effects of naringenin on bronchial pneumonia in children

期刊: PHARMACOLOGY RESEARCH & PERSPECTIVES, 2021; 9 (4)

Bronchial pneumonia in children is a common infectious disease in toddlers and infants, which may cause hyperpyrexia, pulmonary moist rales, and even ......

Impacts of anti-inflammatory phosphodiesterase inhibitors on a murine model of chronic pulmonary inflammation

期刊: PHARMACOLOGY RESEARCH & PERSPECTIVES, 2021; 9 (4)

Chronic obstructive pulmonary disease (COPD) often tends to respond poorly to glucocorticoid (GC) therapy. Reduced Histone deacetylase-2 (HDAC-2) acti......

A phase I, single and continuous dose administration study on the safety, tolerability, and pharmacokinetics of neorudin, a novel recombinant anticoagulant protein, in healthy subjects

期刊: PHARMACOLOGY RESEARCH & PERSPECTIVES, 2021; 9 (3)

The aim of this study was to evaluate the tolerability, safety, and pharmacokinetics of single and continuous dose administration of recombinant neoru......

Intervention by clinical pharmacists can improve blood glucose fluctuation in patients with diabetes and acute myocardial infarction: A propensity score-matched analysis

期刊: PHARMACOLOGY RESEARCH & PERSPECTIVES, 2021; 9 (2)

Acute phase hyperglycemia and exaggerated glucose fluctuation may be associated with poor outcomes in diabetic patients after acute myocardial infarct......

The expression profile of platelet-derived miRNA in coronary artery disease patients with clopidogrel resistance

期刊: PHARMACOLOGY RESEARCH & PERSPECTIVES, 2021; 9 (2)

Clopidogrel is widely used for antiplatelet therapy in patients with coronary artery disease (CAD), but clopidogrel resistance (CR) is relatively comm......

Casticin protected against neuronal injury and inhibited the TLR4/NF-kappa B pathway after middle cerebral artery occlusion in rats

期刊: PHARMACOLOGY RESEARCH & PERSPECTIVES, 2021; 9 (2)

Although stroke is a major human neurological disease, there is a paucity of effective neuroprotectants that can improve its treatment. Casticin is a ......

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