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Investigating the basis for the antidepressant effects of Gleditsiae spina using an integrated metabolomic strategy

期刊: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2021; 24 (4)

Objective(s): Gleditsiae spina (GS) is a natural antidepressant but its mechanisms of action remain unclear. In the present study, taxifolin (Tax) was......

Combination of s-methyl cysteine and protocatechuic acid provided greater lipid-lowering and anti-inflammatory effects in mice liver against chronic alcohol consumption

期刊: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2021; 24 (8)

Objective(s): Protective effects of s-methyl cysteine (SMC) alone, protocatechuic acid (PCA) alone, and SMC plus PCA against chronic ethanol consumpti......

GABAergic neurons in the nucleus accumbens regulate hedonic food intake via orexin-a expression in the lateral hypothalamus

期刊: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2021; 24 (9)

Objective(s): To investigate the regulatory effects of the nucleus accumbens (NAcSh)-lateral hypothalamus (LHA) GABAergic neural pathway on palatable ......

Cardioprotective effects of co-administration of thymoquinone and ischemic postconditioning in diabetic rats

期刊: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2021; 24 (7)

Objective(s): Ischemia/reperfusion (I/R) is a leading cause of myocardial infarction (MI) injury, contributing to excess injury to cardiac tissues inv......

Irisin protects female mice with LPS-induced endometritis through the AMPK/NF-kappa B pathway

期刊: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2021; 24 (9)

Objective(s): This research was designed to determine the role of irisin in lipopolysaccharide (LPS)-induced endometritis in female mice. Materials an......

Effects of the diphenylheptane extract of Alpinia officinarum rhizomes on ethanol-induced gastric ulcers in mice

期刊: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2021; 24 (5)

Objective(s): Experimental studies have revealed that Alpinia officinarum Hance (Zingiberaceae) exhibits a gastrointestinal protective effect. The pre......

Pretreatment with licochalcone a enhances therapeutic activity of rat bone marrow mesenchymal stem cells in animal models of colitis

期刊: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2021; 24 (8)

Objective(s): Colitis has a high prevalence rate, limited treatment options, and needs to be solved urgently. Application of Licochacone A (LA) or rBM......

Kaempferide improves oxidative stress and inflammation by inhibiting the TLR4/I kappa B alpha/NF-kappa B pathway in obese mice

期刊: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2021; 24 (4)

Objective(s): Kaempferide (Ka), a major natural active component of Tagetes erecta L, has numerous pharmacological effects such as anti-obesity, antic......

Flower extract of Caragana sinica. ameliorates DSS-induced ulcerative colitis by affecting TLR4/NF-KB and TLR4/MAPK signaling pathway in a mouse model

期刊: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2021; 24 (5)

Objective(s): This study aimed to find out the protective effects and preliminary mechanisms of the flower extract of Caragana sinica (FEC) on dextran......

Voltage-gated potassium channels are involved in oxymatrine- regulated islet function in rat islet beta cells and INS-1 cells

期刊: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2021; 24 (4)

Objective(s): Oxymatrine can regulate glucose metabolism. But the underlying mechanisms remain unclear. We investigated the relationship of oxymatrine......

Marine algae as emerging therapeutic alternatives for depression: A review

期刊: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2021; 24 (8)

Depression is a complex heterogeneous brain disorder characterized by a range of symptoms, resulting in psychomotor and cognitive disabilities and sui......

Knockout of PKC theta gene attenuates oleic acid-induced acute lung injury via reduction of inflammation and oxidative stress

期刊: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2021; 24 (7)

Objective(s): Acute respiratory distress syndrome resulting from acute lung injury has become a momentous clinical concern because of high morbidity a......

Thymoquinone against infectious diseases: Perspectives in recent pandemics and future therapeutics

期刊: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2021; 24 (8)

The recent pandemics caused by coronavirus infections have become major challenges in 21st century human health. Scientists are struggling hard to dev......

Sirtuin 3 deficiency promotes acute kidney injury induced by sepsis via mitochondrial dysfunction and apoptosis

期刊: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2021; 24 (5)

Objective(s): To explore the regulation mechanism of Sirtuin 3 (SIRT3) on the mitochondrial function and apoptosis of acute kidney injury (AKI) in sep......

Alpha-lipoic acid could attenuate the effect of chemerin-induced diabetic nephropathy progression

期刊: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2021; 24 (8)

Objective(s): Chemerin is associated with insulin resistance, obesity, and metabolic syndrome. alpha-lipoic acid (alpha-LA) is a potent antioxidant in......

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