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Competitive blocking of salivary gland [F-18]DCFPyL uptake via localized, retrograde ductal injection of non-radioactive DCFPyL: a preclinical study

期刊: EJNMMI RESEARCH, 2021; 11 (1)

BackgroundPSMA-targeted radionuclide therapy (TRT) is a promising treatment for prostate cancer (PCa), but dose-limiting xerostomia can severely limit......

Correlation of [F-18]florbetaben textural features and age of onset of Alzheimer's disease: a principal components analysis approach

期刊: EJNMMI RESEARCH, 2021; 11 (1)

Background: When Alzheimer's disease (AD) is occurring at an early onset before 65 years old, its clinical course is generally more aggressive than in......

Nanobody: a promising toolkit for molecular imaging and disease therapy

期刊: EJNMMI RESEARCH, 2021; 11 (1)

Nanobodies are the recombinant variable domains of heavy-chain-only antibodies, with many unique properties such as small size, excellent solubility, ......

[Tc-99m]Tc-Galacto-RGD(2) integrin alpha(v)beta(3)-targeted imaging as a surrogate for molecular phenotyping in lung cancer: real-world data

期刊: EJNMMI RESEARCH, 2021; 11 (1)

Backgroun: Epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) are beneficial in patients with lung cancer. We explored the clinical va......

Evaluation of F-18-AlF-NOTA-octreotide for imaging neuroendocrine neoplasms: comparison with Ga-68-DOTATATE PET/CT

期刊: EJNMMI RESEARCH, 2021; 11 (1)

Objective: To evaluate the diagnostic efficacy of F-18-AlF-NOTA-octreotide (F-18-OC) PET/CT compared with that of Ga-68-DOTATATE PET/CT. Materials and......

Preoperative prediction of pathological grade in pancreatic ductal adenocarcinoma based on F-18-FDG PET/CT radiomics

期刊: EJNMMI RESEARCH, 2021; 11 (1)

Purpose To develop and validate a machine learning model based on radiomic features derived from F-18-fluorodeoxyglucose (F-18-FDG) positron emission ......

Prognostic value of baseline total metabolic tumour volume of F-18-FDG PET/CT imaging in patients with angioimmunoblastic T-cell lymphoma

期刊: EJNMMI RESEARCH, 2021; 11 (1)

Purpose The aim of this study was to explore the prognostic value of baseline metabolic parameters of F-18-FDG PET/CT imaging in patients with angioim......

Evaluation of image quality with four positron emitters and three preclinical PET/CT systems

期刊: EJNMMI RESEARCH, 2020; 10 (1)

Background We investigated the image quality of C-11, Ga-68, F-18 and Zr-89, which have different positron fractions, physical half-lifes and positron......

Indium-111-labeled CD166-targeted peptide as a potential nuclear imaging agent for detecting colorectal cancer stem-like cells in a xenograft mouse model

期刊: EJNMMI RESEARCH, 2020; 10 (1)

Background Cancer stem cells (CSCs) are involved in drug resistance, metastasis, and relapse of cancers, which can significantly affect tumor therapy.......

The value of F-18-PSMA-1007 PET/CT in identifying non-metastatic high-risk prostate cancer

期刊: EJNMMI RESEARCH, 2020; 10 (1)

Background Clinical management decisions on prostate cancer (PCa) are often based on a determination of risk. Ga-68-prostate-specific membrane antigen......

Comparative evaluation of Ga-68-labelled TATEs: the impact of chelators on imaging

期刊: EJNMMI RESEARCH, 2020; 10 (1)

Background Ga-68-labelled peptides targeting somatostatin receptor 2 (SSTR2) have demonstrated encouraging results in managing patients with neuroendo......

A near-infrared probe for non-invasively monitoring cerebrospinal fluid flow by F-18-positron emitting tomography and fluorescence

期刊: EJNMMI RESEARCH, 2020; 10 (1)

Purpose Knowing the precise flow of cerebrospinal fluid (CSF) is important in the management of multiple neurological diseases. Technology for non-inv......

PD-L1 expression correlation with metabolic parameters of FDG PET/CT and clinicopathological characteristics in non-small cell lung cancer

期刊: EJNMMI RESEARCH, 2020; 10 (1)

Background Immunotherapy targeting programmed cell death 1 (PD-1) or its ligand 1 (PD-L1) has shown promising results in non-small cell lung cancer (N......

The flow-metabolism ratio might predict treatment response and survival in patients with locally advanced esophageal squamous cell carcinoma

期刊: EJNMMI RESEARCH, 2020; 10 (1)

Background Perfusion CT can offer functional information about tumor angiogenesis, and F-18-FDG PET/CT quantifies the glucose metabolic activity of tu......

Synthesis of a novel Zr-89-labeled HER2 affibody and its application study in tumor PET imaging

期刊: EJNMMI RESEARCH, 2020; 10 (1)

Background Human epidermal growth factor receptor-2 (HER2) is an essential biomarker for tumor treatment. Affibody is an ideal vector for preparing HE......

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