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Mouse α-Defensins: Structural and Functional Analysis of the 17 Cryptdin Isoforms Identified from a Single Jejunal Crypt

期刊: INFECTION AND IMMUNITY, 2023; 91 (1)

Mouse alpha-defensins, better known as cryptdins, are host protective antimicrobial peptides produced in the intestinal crypt by Paneth cells. To date......

Treatment of Bacterial Infections with β-Lactams: Cooperation with Innate Immunity

期刊: INFECTION AND IMMUNITY, 2023; 91 (2)

beta-Lactams are the most widely prescribed antibiotics used for the control and treatment of bacterial infections. The direct effect of beta-lactams ......

Identification of Multiple Iron Uptake Mechanisms in Enterococcus faecalis and Their Relationship to Virulence

期刊: INFECTION AND IMMUNITY, 2023; 91 (4)

Among the unfavorable conditions bacteria encounter within the host is restricted access to essential trace metals such as iron. To overcome iron defi......

Inflammation plays a critical role in damage to the bronchiolar epithelium induced by Trueperella pyogenes in vitro and in vivo

期刊: INFECTION AND IMMUNITY, 2023; ()

Trueperella pyogenes can cause severe pulmonary disease in swine, but the mechanism of pathogenesis is not well defined. T. pyogenes-induced damage to......

Distinct Molecular Features of NIeG Type 3 Secreted Effectors Allow for Different Roles during Citrobacter rodentium Infection in Mice

期刊: INFECTION AND IMMUNITY, 2023; 91 (1)

The NIeGs are the largest family of type 3 secreted effectors in attaching and effacing (A/E) pathogens, such as enterohemorrhagic Escherichia coli (E......

A Member of an Ancient Family of Bacterial Amino Acids Transporters Contributes to Chlamydia Nutritional Virulence and Immune Evasion

期刊: INFECTION AND IMMUNITY, 2023; 91 (3)

Many obligate intracellular bacteria, including members of the genus Chlamydia, cannot synthesize a variety of amino acids de novo and acquire these f......

Erp and Rev Adhesins of the Lyme Disease Spirochete's Ubiquitous cp32 Prophages Assist the Bacterium during Vertebrate Infection

期刊: INFECTION AND IMMUNITY, 2023; 91 (3)

Almost all spirochetes in the genus Borrelia (sensu lato) naturally contain multiple variants of closely related prophages. In the Lyme disease borrel......

StkP- and PhpP-Mediated Posttranslational Modifications Modulate the S. pneumoniae Metabolism, Polysaccharide Capsule, and Virulence

期刊: INFECTION AND IMMUNITY, 2023; 91 (4)

Pneumococcal Ser/Thr kinase (StkP) and its cognate phosphatase (PhpP) play a crucial role in bacterial cytokinesis. However, their individual and reci......

The Mystery of Candida albicans Hyphal Morphogenesis in the Macrophage Phagolysosome

期刊: INFECTION AND IMMUNITY, 2023; 91 (5)

C. albicans transitions between budding yeast and filamentous hyphal forms in a process that is tightly associated with its virulence. This transition......

Susceptibility to Cryptococcus neoformans Infection with Bruton's Tyrosine Kinase Inhibition

期刊: INFECTION AND IMMUNITY, 2023; 91 (8)

Patients receiving the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib have an increased likelihood of fungal infections. The objectives of this st......

A Positively Selected fur-R88H Mutation Enhances Helicobacter pylori Fitness in a High-Salt Environment and Alters Fur-Dependent Regulation of Gene Expression

期刊: INFECTION AND IMMUNITY, 2023; 91 (2)

Both Helicobacter pylori infection and a high-salt diet are risk factors for gastric cancer. We previously showed that a mutation in fur (encoding the......

Tryptophan Availability during Persistence of Chlamydia trachomatis Directly Impacts Expression of Chlamydial Cell Division Proteins

期刊: INFECTION AND IMMUNITY, 2023; 91 (2)

Chlamydia is an obligate intracellular pathogen with a highly reduced genome devoid of major stress response genes like relA and spoT, which mediate t......

Regulation of Bacterial Two-Component Systems by Cardiolipin

期刊: INFECTION AND IMMUNITY, 2023; 91 (4)

The regulation of membrane protein activity for cellular functions is critically dependent on the composition of phospholipid membranes. Cardiolipin, ......

Arginine Metabolism Powers Salmonella Resistance to Oxidative Stress

期刊: INFECTION AND IMMUNITY, 2023; 91 (6)

Salmonella invades host cells and replicates inside acidified, remodeled vacuoles that are exposed to reactive oxygen species (ROS) generated by the i......

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