Although mice normally enter labor when their ovaries stop producing progesterone (luteolysis), parturition can also be triggered in this species thro......
Human T cell receptors (TCRs) are critical for mediating immune responses to pathogens and tumors and regulating self-antigen recognition. Yet, variat......
T cells are a critical component of the response to SARS-CoV-2, but their kinetics after infection and vacci-nation are insufficiently understood. Usi......
Repetitive pathogen exposure leads to the dominant outgrowth of T cell clones with high T cell receptor (TCR) affinity to the relevant pathogen-associ......
In early life, susceptibility to invasive infection skews toward a small subset of microbes, whereas other path-ogens associated with diseases later i......
In cancer patients, dendritic cells (DCs) in tumor-draining lymph nodes can present antigens to naive T cells in ways that break immunological toleran......
Improvements in tumor immunotherapies depend on better understanding of the anti-tumor T cell response. By studying human tumor-draining lymph nodes (......
In allogeneic hematopoietic stem cell transplantation, donor ab T cells attack recipient tissues, causing graft-versus-host disease (GVHD), a major ca......
Crohn's disease (CD) is a chronic gastrointestinal disease that is increasing in prevalence worldwide. CD is multifactorial, involving the complex int......
Neuronal signals have emerged as pivotal regulators of group 2 innate lymphoid cells (ILC2s) that regulate tissue homeostasis and allergic inflammatio......
Maladaptive, non-resolving inflammation contributes to chronic inflammatory diseases such as atheroscle-rosis. Because macrophages remove necrotic cel......
The accurate selection of neoantigens that bind to class I human leukocyte antigen (HLA) and are recognized by autologous T cells is a crucial step in......
T cell-excluded tumors are less responsive to immunotherapies. In this issue of Immunity, Taifour et al. show that secretion of the cytokine Chi3l1 by......
Exhausted T cells are largely hampered by epigenetically enforced mechanisms that limit their effector po-tential. In this issue of Immunity, Beltra e......
