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T cell receptor signaling in the differentiation and plasticity of CD4+T cells

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2023; 69 ()

CD4+ T cells are critical components of the adaptive immune system. The T cell receptor (TCR) and co-receptor signaling cascades shape the phenotype a......

Role of lipid signalling in extracellular vesicles-mediated cell-to-cell communication

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2023; 73 ()

Lipid signalling plays a crucial role in extracellular vesicle (EV)-mediated cell-to-cell communication. Extra-cellular vesicles are small membrane-bo......

Extracellular vesicles: Emerging mediators of cell communication in gastrointestinal cancers exhibiting metabolic abnormalities

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2023; 73 ()

There is a complex interaction between pro-tumoural and anti-tumoural networks in the tumour microenvironment (TME). Throughout tumourigenesis, commun......

Role of exosomes in transferring chemoresistance through modulation of cancer glycolytic cell metabolism

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2023; 73 ()

Chemoresistance constitute a major obstacle in cancer treatment, leading to limited options and decreased patient survival. Recent studies have reveal......

Immuno-metabolic control of the balance between Th17-polarized and regulatory T-cells during HIV infection

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2023; 69 ()

Th17-polarized CD4+ effector T-cells together with their immunosuppressive regulatory T-cell (Treg) counterparts, with transcriptional profiles govern......

The cytokine trio - visfatin, placental growth factor and fractalkine - and their role in myocardial infarction with non-obstructive coronary arteries (MINOCA)

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2023; 74 ()

Myocardial infarction with nonobstructive coronary arteries (MINOCA) remains a puzzling clinical entity. It is characterized by clinical evidence of m......

Recent progress and prospects for anti-cytokine therapy in preclinical and clinical acute lung injury

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2023; 71 ()

Acute respiratory distress syndrome (ARDS) is a heterogeneous cause of respiratory failure that has a rapid onset, a high mortality rate, and for whic......

Brain-derived neurotrophic factor: Its role in energy balance and cancer cachexia

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2023; 71-72 ()

Brain-derived neurotrophic factor (BDNF) plays an important role in the development of the central and peripheral nervous system during embryogenesis.......

Role of gremlin-1 in the pathophysiology of the adipose tissues

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2023; 69 ()

Gremlin-1 is a secreted bone morphogenetic protein (BMP) antagonist playing a pivotal role in the regulation of tissue formation and embryonic develop......

TGF-β mediated drug resistance in solid cancer

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2023; 71-72 ()

Transforming growth factor beta (TGF-beta) is an important signaling molecule which is expressed in three different isoforms in mammals (i.e. TGF-beta......

Multifaceted role of CD14 in innate immunity and tissue homeostasis

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2023; 74 ()

CD14 is a co-receptor of Toll-like receptor (TLR)-4, with a critical role in innate immune responses. CD14 recognizes bacterial lipopolysaccharides, p......

Preexisting immunity: Barrier or bridge to effective oncolytic virus therapy?

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2023; 70 ()

Oncolytic viruses (OVs) represent a highly promising treatment strategy for a wide range of cancers, by medi-ating both the direct killing of tumor ce......

The role of Extracellular Vesicles in glycolytic and lipid metabolic reprogramming of cancer cells: Consequences for drug resistance

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2023; 73 ()

In order to adapt to a higher proliferative rate and an increased demand for energy sources, cancer cells rewire their metabolic pathways, a process c......

Proteomics analysis of circulating small extracellular vesicles: Focus on the contribution of EVs to tumor metabolism

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2023; 73 ()

The term small extracellular vesicle (sEV) is a comprehensive term that includes any type of cell-derived, membrane-delimited particle that has a diam......

The impact of adipokines on vascular networks in adipose tissue

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2023; 69 ()

Adipose tissue (AT) is a highly active and plastic endocrine organ. It secretes numerous soluble molecules known as adipokines, which act locally to A......

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