Blocking PD-1/PD-L1 signaling transforms cancer therapy and is assumed to unleash exhausted tumor -reac-tive CD8+ T cells in the tumor microenvironmen......
The target DNA specificity of the CRISPR-associated genome editor nuclease Cas9 is determined by complementarity to a 20-nucleotide segment in its gui......
Neurons build synaptic contacts using different protein combinations that define the specificity, function, and plasticity potential of synapses; howe......
RNA sequencing in situ allows for whole-transcriptome characterization at high resolution, while retaining spatial information. These data present an ......
Metabolism is deeply intertwined with aging. Effects of metabolic interventions on aging have been explained with intracellular metabolism, growth con......
In Drosophila, a dedicated olfactory channel senses a male pheromone, cis-vaccenyl acetate (cVA), promoting female courtship while repelling males. He......
Membrane tension has been proposed to mechanically couple processes along the cell's boundary. In this issue of Cell, De Belly et al. show that local ......
The number one cause of human fetal death are defects in heart development. Because the human embryonic heart is inaccessible and the impacts of mutat......
The cortex influences movement by widespread top-down projections to many nervous system regions. Skilled forelimb movements require brainstem circuit......
Glucose is the main source of energy for cells. In this issue of Cell, a study now shows that glucose has additional non-energetic functions, acting a......
