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Propofol protects H9C2 cells against hypoxia/reoxygenation injury through miR-449a and NR4A2

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021; 22 (4)

Propofol has been revealed to protect cardiomyocytes against myocardial ischemia injury, although the underlying mechanism remains incompletely unders......

Inhibition of autophagy promotes human RSV NS1-induced inflammation and apoptosis in vitro

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021; 22 (4)

Human respiratory syncytial virus (RSV) is a major health challenge due to the lack of a safe and effective vaccine and antiviral drugs. RSV non-struc......

A novel therapy for granulomatous lobular mastitis: Local heat therapy

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021; 22 (4)

Granulomatous lobular mastitis (GLM) is a chronic inflammatory breast condition that is characterized by granulomatous inflammation. GLM remains a ref......

Construction and evaluation of a novel tissue-engineered bone device

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021; 22 (4)

Tissue-engineered bones (TEB) are a promising strategy for treating large segmental bone defects. However, the application of TEB is greatly limited b......

Metformin attenuates angiotensin II-induced cardiomyocyte hypertrophy by upregulating the MuRF1 and MAFbx pathway

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021; 22 (5)

Pathological cardiac hypertrophy induced by aging and neurohumoral activation, such as angiotensin II (Ang II) activation, is an independent risk fact......

Roles and regulatory mechanisms of miR-30b in cancer, cardiovascular disease, and metabolic disorders (Review)

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021; 21 (1)

MicroRNAs (miRNAs) are non-coding RNAs 21-23 nucleotides in length that regulate gene expression, and thereby modulate signaling pathways and protein ......

Clinical characteristics and infectivity of asymptomatic carriers of SARS-CoV-2 (Review)

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021; 21 (2)

Since December 2019, the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. At present, confirmed pa......

Phenoxythiophene sulfonamide compound B355252 protects neuronal cells against glutamate-induced excitotoxicity by attenuating mitochondrial fission and the nuclear translocation of AIF

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021; 21 (3)

Glutamate neurotoxicity has been implicated in the initiation and progression of various neurological and neurodegenerative disorders. Therefore, it i......

Visual impairment in immunoglobulin G4-related disease: A case report

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021; 21 (3)

The present study reports on the case of a 50-year-old male with sinusitis, diplopia, secretory otitis media and skin eczema for >14 years. The pat......

Mechanism of circadian regulation of the NRF2/ARE pathway in renal ischemia-reperfusion

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021; 21 (3)

The nuclear erythroid 2-related factor 2 (NRF2)/antioxidant response element (ARE) pathway has been shown to provide strong protection against oxidati......

4-Methoxybenzylalcohol protects brain microvascular endothelial cells against oxygen-glucose deprivation/reperfusion-induced injury via activation of the PI3K/AKT signaling pathway

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021; 21 (3)

Damage to the blood-brain barrier (BBB) during the process of cerebral ischemic injury is a key factor that affects the treatment of this condition. T......

A systematic review and meta-analysis of minimally invasive vs. standard percutaneous nephrolithotomy in the surgical management of renal stones

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021; 21 (3)

The present study aimed to assess current evidence on the effectiveness and safety of minimally invasive vs. standard percutaneous nephrolithotomy (PC......

Effect and related mechanism of Yinchenhao decoction on mice with lithogenic diet-induced cholelithiasis

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021; 21 (4)

The aim of the present study was to investigate the effects and the underlying mechanisms of Yinchenhao Decoction (YCHD), a traditional Chinese medici......

Biological effects of NODAL on endometrial cancer cells and its underlying mechanisms

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021; 21 (4)

Activin A receptor type 1C (ALK7) and its ligand nodal growth differentiation factor (NODAL) serve numerous roles in cancer cells, including regulatin......

Meta-analysis of laboratory results in patients with severe coronavirus disease 2019

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021; 21 (5)

The aim of the present study was to analyze the differences in laboratory results between patients with severe and moderate coronavirus disease 2019 (......

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