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2018 2
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2020 5
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2022 14
2023 24
2024 5

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56 results

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Page 1
Activation of Pancreatic Acinar FXR Protects against Pancreatitis via Osgin1-Mediated Restoration of Efficient Autophagy.
Zheng Y, Sun W, Wang Z, Liu J, Shan C, He C, Li B, Hu X, Zhu W, Liu L, Lan F, Jiang C, Zhao C, Li X, Sun N. Zheng Y, et al. Research (Wash D C). 2022 Nov 2;2022:9784081. doi: 10.34133/2022/9784081. eCollection 2022. Research (Wash D C). 2022. PMID: 36405253 Free PMC article.
In this study, we initially observed a marked increase of nuclear FXR in pancreatic tissues of human patients with pancreatitis. Deleting the FXR in pancreatic acinar cells (FXR(acinardelta/delta) ) led to more severe pancreatitis in mouse models of caerulein-induce …
In this study, we initially observed a marked increase of nuclear FXR in pancreatic tissues of human patients with pancreatitis. Dele …
Cold-Induced Reprogramming of Subcutaneous White Adipose Tissue Assessed by Single-Cell and Single-Nucleus RNA Sequencing.
Liu Q, Long Q, Zhao J, Wu W, Lin Z, Sun W, Gu P, Deng T, Loomes KM, Wu D, Kong APS, Zhou J, Cheng AS, Hui HX. Liu Q, et al. Research (Wash D C). 2023 Jun 28;6:0182. doi: 10.34133/research.0182. eCollection 2023. Research (Wash D C). 2023. PMID: 37398933 Free PMC article.
Adipose browning has demonstrated therapeutic potentials in several diseases. Here, by conducting transcriptomic profiling at the single-cell and single-nucleus resolution, we reconstituted the cellular atlas in mouse inguinal subcutaneous white adipose tissue (iWAT …
Adipose browning has demonstrated therapeutic potentials in several diseases. Here, by conducting transcriptomic profiling at the single- …
Age- and Microbiota-Dependent Cell Stemness Plasticity Revealed by Cattle Cell Landscape.
Wu JJ, Zhu S, Tang YF, Gu F, Valencak TG, Liu JX, Sun HZ. Wu JJ, et al. Research (Wash D C). 2023;6:0025. doi: 10.34133/research.0025. Epub 2023 Jan 13. Research (Wash D C). 2023. PMID: 37040481 Free PMC article.
A comprehensive single-cell transcriptomic atlas covering 235,941 high-quality single cells and 78 cell types was deciphered. ...By measuring stemness states of epithelial cells in each tissue type, we revealed that the epithelial cells f …
A comprehensive single-cell transcriptomic atlas covering 235,941 high-quality single cells and 78 cell types was decip …
Cellular and Transcriptional Dynamics during Brown Adipose Tissue Regeneration under Acute Injury.
You W, Xu Z, Chen W, Yang X, Liu S, Wang L, Tu Y, Zhou Y, Valencak TG, Wang Y, Kuang S, Shan T. You W, et al. Research (Wash D C). 2023 Nov 8;6:0268. doi: 10.34133/research.0268. eCollection 2023. Research (Wash D C). 2023. PMID: 38434240 Free PMC article.
Brown adipose tissue (BAT) is the major site of non-shivering thermogenesis and crucial for systemic metabolism. ...Here, we established a novel BAT injury and regeneration model (BAT-IR) in mice and performed single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq …
Brown adipose tissue (BAT) is the major site of non-shivering thermogenesis and crucial for systemic metabolism. ...Here, we establis …
The Dynamic Inflammatory Tissue Microenvironment: Signality and Disease Therapy by Biomaterials.
Mata R, Yao Y, Cao W, Ding J, Zhou T, Zhai Z, Gao C. Mata R, et al. Research (Wash D C). 2021 Feb 3;2021:4189516. doi: 10.34133/2021/4189516. eCollection 2021. Research (Wash D C). 2021. PMID: 33623917 Free PMC article. Review.
Tissue regeneration is an active multiplex process involving the dynamic inflammatory microenvironment. ...This review discusses the recent advances in molecular interactions of immune cells, controlled shift of pro- to anti-inflammation, reparative inflammatory met …
Tissue regeneration is an active multiplex process involving the dynamic inflammatory microenvironment. ...This review discusses the …
Biomimetic Gland Models with Engineered Stratagems.
Lin X, Sun L, Lu M, Zhao Y. Lin X, et al. Research (Wash D C). 2023 Sep 15;6:0232. doi: 10.34133/research.0232. eCollection 2023. Research (Wash D C). 2023. PMID: 37719047 Free PMC article. Review.
As extensively distributed tissues throughout the human body, glands play a critical role in various physiological processes. ...In the biological field, the researchers focus on optimizing the cell sources and culture techniques to reconstruct the specific structur …
As extensively distributed tissues throughout the human body, glands play a critical role in various physiological processes. ...In t …
Low-Temperature Photothermal Therapy: Strategies and Applications.
Yi X, Duan QY, Wu FG. Yi X, et al. Research (Wash D C). 2021 May 7;2021:9816594. doi: 10.34133/2021/9816594. eCollection 2021. Research (Wash D C). 2021. PMID: 34041494 Free PMC article. Review.
Although photothermal therapy (PTT) with the assistance of nanotechnology has been considered as an indispensable strategy in the biomedical field, it still encounters some severe problems that need to be solved. Excessive heat can induce treated cells to develop thermal r …
Although photothermal therapy (PTT) with the assistance of nanotechnology has been considered as an indispensable strategy in the biomedical …
Trends and Potential of Machine Learning and Deep Learning in Drug Study at Single-Cell Level.
Qi R, Zou Q. Qi R, et al. Research (Wash D C). 2023;6:0050. doi: 10.34133/research.0050. Epub 2023 Mar 9. Research (Wash D C). 2023. PMID: 36930772 Free PMC article. Review.
Study drugs at the single-cell level are perspective to overcome minimal residual disease caused by subclonal resistant cancer cells retained after initial curative therapy. Fortunately, machine learning techniques can help us understand how different types of ce …
Study drugs at the single-cell level are perspective to overcome minimal residual disease caused by subclonal resistant cancer cel …
Protective and Adverse Roles of DDX3X in Different Cell Types in Nonalcoholic Steatohepatitis Progression.
Yang S, Zhou L, Zhao T, Zhu H, Luo T, Jiang K, Shi X, Chen C, Zhang H, Zhao S, Zou X, Zhuge Y, Wang F, Wang L, Jiang M, Xu B. Yang S, et al. Research (Wash D C). 2023 Dec 8;6:0275. doi: 10.34133/research.0275. eCollection 2023. Research (Wash D C). 2023. PMID: 38090607 Free PMC article.
However, the role of DDX3X in NASH remains unclear. We characterized the cell type-specific roles of DDX3X in NASH. Human liver tissues from NASH patients and normal control subjects were collected to assess DDX3X expression and distribution. ...The study demonstrat …
However, the role of DDX3X in NASH remains unclear. We characterized the cell type-specific roles of DDX3X in NASH. Human liver ti …
Electrical Stimulation Enabled via Electrospun Piezoelectric Polymeric Nanofibers for Tissue Regeneration.
Xia G, Song B, Fang J. Xia G, et al. Research (Wash D C). 2022 Aug 2;2022:9896274. doi: 10.34133/2022/9896274. eCollection 2022. Research (Wash D C). 2022. PMID: 36061820 Free PMC article. Review.
In this review, brief introduction of piezoelectric polymer and electrospinning technology is elucidated first. Afterward, we highlight the activating strategies (e.g., cell traction, physiological activity, and ultrasound) of piezoelectric stimulation and the interaction …
In this review, brief introduction of piezoelectric polymer and electrospinning technology is elucidated first. Afterward, we highlight the …
56 results