JAMA Cardiol:颅内动脉粥样硬化疾病竟有种族差异?

2017-12-04 佚名 国际循环

近期,来自社区动脉粥样硬化风险(ARIC)研究的最新数据显示,与白种人相比,ICAD在黑人男性中更常见,这可能是后者卒中风险较高的原因所在。

众所周知,约有11%的颅内斑块患者并无显著性病变,无法被血管造影所发现。随着三维血管壁核磁共振成像的应用,大量非狭窄斑块得以被发现,缺血性卒中的主要原因——颅内动脉粥样硬化性疾病(ICAD)患病率显著增加,但既往尚无研究探讨一般人群中ICAD患病率的种族差异。近期,来自社区动脉粥样硬化风险(ARIC)研究的最新数据显示,与白种人相比,ICAD在黑人男性中更常见,这可能是后者卒中风险较高的原因所在。

研究者约翰霍普金斯大学医学院的Bruce A Wasserman等对ARIC研究中行三维颅内血管磁共振成像的1752例成人进行分析,评估ICAD患病率及其相关危险因素的种族差异。受试患者的平均年龄为77.6岁,女性及黑人比例分别为58.4%和29.6%。分析显示,与黑人女性、白种人男性及白种人女性相比,黑人男性的ICAD患病率更高(50.9% vs. 35.9% vs. 35.5% vs. 30.2%,P<0.001),多发斑块发生率也更高(22.4% vs. 12.1% vs. 10.7% vs. 8.7%,P<0.01)。这提示,ICAD在老年人尤其是黑人男性中高度流行,而美国黑人男性继发于ICAD的卒中风险增加可能是其斑块或多发斑块发生率较高所致。

此外,研究发现,ICAD的患病率随年龄增长而增加,黑人男性、白种人男性及女性的患病率分别在68岁、84岁及88岁前达50%;黑人女性的ICAD患病率则一直低于50%。就ICAD的危险因素而言,研究发现,中年吸烟及糖尿病与黑人而非白种人晚年ICAD的发病具有较强相关性,中年高血压及高脂血症则与黑人及白种人晚年ICAD的发病均相关。此外,中年高血压还与颅内斑块较大具有相关性,这提示,不论晚年风险状态如何,对于ICAD患者均应进行早期危险因素管理

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    2017-12-11 jihuaijun1112

    学习学习学习

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1781829, encodeId=0de01e8182903, content=<a href='/topic/show?id=5db8409ed8' target=_blank style='color:#2F92EE;'>#Cardiol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4097, encryptionId=5db8409ed8, topicName=Cardiol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Fri Sep 21 19:55:00 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944506, encodeId=c2fb194450657, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Sun Mar 18 20:55:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2053347, encodeId=36a4205334e57, content=<a href='/topic/show?id=317b10038659' target=_blank style='color:#2F92EE;'>#颅内动脉粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100386, encryptionId=317b10038659, topicName=颅内动脉粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Fri Mar 30 20:55:00 CST 2018, time=2018-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268461, encodeId=40972684617f, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Dec 11 00:07:36 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353573, encodeId=8d0013535e3bd, content=<a href='/topic/show?id=29e1e4781f1' target=_blank style='color:#2F92EE;'>#种族差异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74781, encryptionId=29e1e4781f1, topicName=种族差异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Dec 06 13:55:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267202, encodeId=1ea326e202fb, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Wed Dec 06 08:58:49 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266901, encodeId=7cd2266901c9, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Dec 05 07:19:18 CST 2017, time=2017-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266872, encodeId=8b392668e2dc, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Tue Dec 05 06:35:00 CST 2017, time=2017-12-05, status=1, ipAttribution=)]
    2017-12-06 半夏微凉

    学习了谢谢分享

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1781829, encodeId=0de01e8182903, content=<a href='/topic/show?id=5db8409ed8' target=_blank style='color:#2F92EE;'>#Cardiol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4097, encryptionId=5db8409ed8, topicName=Cardiol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Fri Sep 21 19:55:00 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944506, encodeId=c2fb194450657, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Sun Mar 18 20:55:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2053347, encodeId=36a4205334e57, content=<a href='/topic/show?id=317b10038659' target=_blank style='color:#2F92EE;'>#颅内动脉粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100386, encryptionId=317b10038659, topicName=颅内动脉粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Fri Mar 30 20:55:00 CST 2018, time=2018-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268461, encodeId=40972684617f, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Dec 11 00:07:36 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353573, encodeId=8d0013535e3bd, content=<a href='/topic/show?id=29e1e4781f1' target=_blank style='color:#2F92EE;'>#种族差异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74781, encryptionId=29e1e4781f1, topicName=种族差异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Dec 06 13:55:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267202, encodeId=1ea326e202fb, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Wed Dec 06 08:58:49 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266901, encodeId=7cd2266901c9, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Dec 05 07:19:18 CST 2017, time=2017-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266872, encodeId=8b392668e2dc, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Tue Dec 05 06:35:00 CST 2017, time=2017-12-05, status=1, ipAttribution=)]
    2017-12-05 明月清辉

    谢谢分享.学习了

    0

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    2017-12-05 chunjianf

    学习了.谢谢分享

    0

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