SCI REP:红细胞分布宽度是2型糖尿病患者用药及预后的重要指标!

2017-06-03 xing.T MedSci原创

这些数据表明,2型糖尿病患者高水平的红细胞分布宽度提示了较高的糖尿病肾病风险和较差的糖尿病肾病预后。

红细胞分布宽度是否可以作为糖尿病肾病(DN)潜在的指标目前尚不清楚。

近日,Scientific reports 杂志上发表了一篇研究文章,研究人员共纳入了809名2型糖尿病患者,将其按红细胞分布宽度大小的四分位数分为4组:Q1≤12.4(n=229),12.4
研究人员发现相比于Q1组,Q4组患者年龄较大、病程较长、收缩压较高、血尿素氮水平较高、肌酐较高、尿酸以及蛋白尿水平较高,但是血红蛋白、血清白蛋白和糖化血红蛋白均有所降低。此外,相比于Q1组患者,Q3组和Q4组患者糖尿病肾病、糖尿病周围神经病变、高血压和冠心病的发生率也明显增高。药物,包括钙通道阻滞剂和抗血小板治疗在Q3或Q4组的使用频率也要显著高于Q1组。

此外,Logistic回归分析表明抗血小板治疗(比值比为2.065)、高血压(比值比为2.819)、肌酐(比值比为4.473)和蛋白尿(比值比为2.085)与Q4组水平呈正相关,但较高的血红蛋白(比值比为0.021)和血清钙水平(比值比为0.178)与Q4组呈负相关。

这些数据表明,2型糖尿病患者高水平的红细胞分布宽度提示了较高的糖尿病肾病风险和较差的糖尿病肾病预后。

原始出处:

Xiao-fen Xiong, et al. Red cell distribution width as a significant indicator of medication and prognosis in type 2 diabetic patients. Scientific reports. 2017. https://www.nature.com/articles/s41598-017-02904-9

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  5. 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    2017-06-04 Jackie Li

    学习

    0

  6. 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    2017-06-03 jiuling

    学习了1谢谢分享

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jun 03 12:57:44 CST 2017, time=2017-06-03, status=1, ipAttribution=)]
    2017-06-03 lovetcm

    确实有不少研究红细胞分布宽度但是他的最终的临床意义还是有争议的

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1670198, encodeId=20f316e0198f2, content=<a href='/topic/show?id=0329e715658' target=_blank style='color:#2F92EE;'>#红细胞分布宽度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77156, encryptionId=0329e715658, topicName=红细胞分布宽度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=642526597709, createdName=一闲, createdTime=Sat Dec 23 11:32:00 CST 2017, time=2017-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1281956, encodeId=582f1281956fe, content=<a href='/topic/show?id=3dece71531e' target=_blank style='color:#2F92EE;'>#红细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77153, encryptionId=3dece71531e, topicName=红细胞)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=418d1603809, createdName=jiuling, createdTime=Sat Jun 03 23:05:48 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206063, encodeId=7759206063ce, content=确实有不少研究红细胞分布宽度但是他的最终的临床意义还是有争议的, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jun 03 17:23:36 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206058, encodeId=87ad20605893, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sat Jun 03 17:10:18 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206025, encodeId=83f22060252d, content=学习啦谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sat Jun 03 15:37:50 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206005, encodeId=f2922060052c, content=,谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jun 03 12:57:44 CST 2017, time=2017-06-03, status=1, ipAttribution=)]
    2017-06-03 dhzzm

    学习了分享了

    0

  9. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=418d1603809, createdName=jiuling, createdTime=Sat Jun 03 23:05:48 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206063, encodeId=7759206063ce, content=确实有不少研究红细胞分布宽度但是他的最终的临床意义还是有争议的, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jun 03 17:23:36 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206058, encodeId=87ad20605893, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, 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createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jun 03 12:57:44 CST 2017, time=2017-06-03, status=1, ipAttribution=)]
    2017-06-03 tanxingdoctor

    学习啦谢谢分享

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=418d1603809, createdName=jiuling, createdTime=Sat Jun 03 23:05:48 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206063, encodeId=7759206063ce, content=确实有不少研究红细胞分布宽度但是他的最终的临床意义还是有争议的, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jun 03 17:23:36 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206058, encodeId=87ad20605893, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sat Jun 03 17:10:18 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206025, encodeId=83f22060252d, content=学习啦谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sat Jun 03 15:37:50 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206005, encodeId=f2922060052c, content=,谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jun 03 12:57:44 CST 2017, time=2017-06-03, status=1, ipAttribution=)]
    2017-06-03 清风拂面

    ,谢谢分享,学习了

    0

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  美国一项研究表明,红细胞分布宽度(RDW)与经皮冠状动脉介入治疗(PCI)术后大出血呈独立线性相关。论文5月20日在线发表于《美国心脏杂志》(American Heart Journal)。   研究纳入6689例倾向行PCI的患者,获取患者PCI术前的全血细胞计数中的RDW数据。以血细胞比容减少≥12%,血红蛋白降低≥4,压缩红细胞输注≥2单位,腹膜后或胃肠道或颅内出血