Int J Cardiol:白蛋白尿能更好地预测房颤患者栓塞事件的发生

2016-07-26 phylis 译 MedSci原创

背景:在管理非瓣膜性心房颤动患者(NVAF)上,准确的危险分层是重要。然而,一个队列研究显示,根据CHA2DS2-VASc评分真正意义上的“低风险”者,每年缺血性卒中发生率在1.61%。研究者旨在找出更多的指标,评估其预测血栓事件(TE)的能力。方法:研究者将58例TE患者分为血栓形成组,157例非TE患者分为非血栓组。对这些患者的临床参数进行单因素非条件Logistic回归分析筛选风险的界值点。

背景:在管理非瓣膜性心房颤动患者(NVAF)上,准确的危险分层是重要。然而,一个队列研究显示,根据CHA2DS2-VASc评分真正意义上的“低风险”者,每年缺血性卒中发生率在1.61%。研究者旨在找出更多的指标,评估其预测血栓事件(TE)的能力。

方法:研究者将58例TE患者分为血栓形成组,157例非TE患者分为非血栓组。对这些患者的临床参数进行单因素非条件Logistic回归分析筛选风险的界值点。然后,研究者形成了CHA2DS2-VASc-UA2评分,并与CHA2DS2-VASc评分进行比较。

结果:血栓组UA的平均值明显高于非血栓组(0.1 VS 0.0g/l,P<0.01)。非条件Logistic回归分析结果表明,UA的OR为40.98(95%CI:3.58-468.88,P<0.01)。最佳分界点为0.03g/L, UA曲线下面积(AUC)0.700。ROC曲线分析结果表明, CHA2DS2-VASc-UA2评分AUC高于CHA2DS2-VASc评分(0.873 vs 0.860)。

结论:UA≥0.03g/L是非瓣膜性房颤患者的TE的独立预测因素。与CHA2DS2-VASc评分相比,CHA2DS2-VASc-UA2评分可能能更好地预测TE的发生。

原始出处:

He H, Guo J, Zhang A. The value of urine albumin in predicting thromboembolic events for patients with non-valvular atrial fibrillation. Int J Cardiol. 2016 Jul 11


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    2016-10-11 ylzr123

    好文值得点赞!继续关注学习。

    0

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    2016-09-25 1e10c84am36(暂无匿称)

    文章很好值得关注

    0

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    2016-07-27 珙桐
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