Hypertension:诊室、中心和动态血压可预测老年人首次卒中

2021-07-16 MedSci原创 MedSci原创

在以老年人群为主的队列中,诊室舒张压与卒中发生的相关性较弱;中心血压变量不能预测卒中。然而,在多变量竞争风险分析中,动态收缩压和舒张压值都与卒中显著相关。此外,动态舒张压比动态收缩压能更好地预测卒中。

高血压是卒中最常见且可改变的危险因素。诊室血压(BP)测量在确定高血压对卒中的影响方面可能存在局限性。

近日,血管权威杂志Hypertension上发表了一篇研究文章,研究人员主要基于老年人群的前瞻性队列比较了诊室、中心和动态血压测量在卒中风险预测方面的价值。

心血管异常和脑损伤(CABL)研究的参与者(n=816;平均年龄为70.8±9.0岁;39.8%占男性)接受了桡动脉血压测量以获得中心血压和24小时动态血压监测结果。

在9.6±3.1年的随访期间,76名参与者(9.3%)发生了卒中。在诊室血压变量中,多变量竞争风险模型中只有舒张压与卒中相关(P=0.016)。没有一个中心血压变量与卒中之间存在显著的关联。相反,在调整临床混杂因素后,所有动态收缩压和舒张压变量均与卒中显著相关(所有P<0.005)。在一个额外的多变量竞争风险模型中,纳入了同一天同一时间获得的动态收缩压和舒张压值,在24小时、白天和夜间期间,舒张压与卒中的相关性比收缩压更密切(所有P<0.05 )。

由此可见,在以老年人群为主的队列中,诊室舒张压与卒中发生的相关性较弱;中心血压变量不能预测卒中。然而,在多变量竞争风险分析中,动态收缩压和舒张压值都与卒中显著相关。此外,动态舒张压比动态收缩压能更好地预测卒中。

原始出处:

Kenji Matsumoto.et al.Office, Central, and Ambulatory Blood Pressure for Predicting First Stroke in Older Adults: A Community-Based Cohort Study.Hypertension.2021.https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.121.17308

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1729043, encodeId=71b81e2904370, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Jun 04 09:44:36 CST 2022, time=2022-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039269, encodeId=48c8203926983, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Wed Apr 06 21:44:36 CST 2022, time=2022-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501544, encodeId=50fc150154477, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sun Jul 18 13:44:36 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1509018, encodeId=e5371509018cc, content=<a href='/topic/show?id=a7c83311e88' target=_blank style='color:#2F92EE;'>#动态血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33117, encryptionId=a7c83311e88, topicName=动态血压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c1e10025437, createdName=limedical1977, createdTime=Sun Jul 18 13:44:36 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026913, encodeId=1b2410269139b, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Jul 17 01:44:36 CST 2021, time=2021-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000269, encodeId=6b4d1000269fb, content=涨知识了👍👍👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=420e5550886, createdName=ms3000000128484655, createdTime=Fri Jul 16 23:56:46 CST 2021, time=2021-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000262, encodeId=6a5210002627b, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6d05550860, createdName=ms8000001686863545, createdTime=Fri Jul 16 23:26:20 CST 2021, time=2021-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000256, encodeId=a03210002568b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ba85550156, createdName=ms2000001188206428, createdTime=Fri Jul 16 23:09:03 CST 2021, time=2021-07-16, status=1, ipAttribution=)]
    2021-07-17 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1729043, encodeId=71b81e2904370, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Jun 04 09:44:36 CST 2022, time=2022-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039269, encodeId=48c8203926983, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Wed Apr 06 21:44:36 CST 2022, time=2022-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501544, encodeId=50fc150154477, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sun Jul 18 13:44:36 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1509018, encodeId=e5371509018cc, content=<a href='/topic/show?id=a7c83311e88' target=_blank style='color:#2F92EE;'>#动态血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33117, encryptionId=a7c83311e88, topicName=动态血压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c1e10025437, createdName=limedical1977, createdTime=Sun Jul 18 13:44:36 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026913, encodeId=1b2410269139b, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Jul 17 01:44:36 CST 2021, time=2021-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000269, encodeId=6b4d1000269fb, content=涨知识了👍👍👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=420e5550886, createdName=ms3000000128484655, createdTime=Fri Jul 16 23:56:46 CST 2021, time=2021-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000262, encodeId=6a5210002627b, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6d05550860, createdName=ms8000001686863545, createdTime=Fri Jul 16 23:26:20 CST 2021, time=2021-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000256, encodeId=a03210002568b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ba85550156, createdName=ms2000001188206428, createdTime=Fri Jul 16 23:09:03 CST 2021, time=2021-07-16, status=1, ipAttribution=)]
    2021-07-16 ms3000000128484655

    涨知识了👍👍👍

    0

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    2021-07-16 ms8000001686863545

    学习

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    2021-07-16 ms2000001188206428

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