NEJM:代谢手术后,体重下降能否给生活方式、糖尿病、心血管危险因素方面带来持久获益呢?

2015-01-05 angletears 译 MedSci原创

体重下降可以在短期内防治和改善,代谢和心血管疾病风险;但是,体重下降带来的这些受益能否随着年龄的增长一直保持下去呢?最近,发表新英格兰杂志上的一篇文章,很好的回答这一问题。Lars博士和他的团队,在瑞典肥胖研究中心进行了一项前瞻性的受控试验,分为减肥手术组和常规的肥胖治疗组。所有登记注册的受试者中,2年的随访数据显示:4047位随访者(平均年龄48岁,平均BMI41),10年的随访数据显示:170

体重下降可以在短期内防治和改善,代谢和心血管疾病风险;但是,体重下降带来的这些受益能否随着年龄的增长一直保持下去呢?[pdf free]


最近,发表新英格兰杂志上的一篇文章,很好的回答这一问题。Lars博士和他的团队,在瑞典肥胖研究中心进行了一项前瞻性的受控试验,分为减肥手术组和常规的肥胖治疗组。所有登记注册的受试者中,2年的随访数据显示:4047位随访者(平均年龄48岁,平均BMI41),10年的随访数据显示:1703位随访者。试验中,2年随访率是86.6%,10年随访率是74.5%。

2年之后,对照组体重平均增加了0.1%,而手术组平均下降了23.4%(P<0.001);10年之后,对照组体重平均增加了1.6%,而手术组平均下降了16.1%(P<0.001)。



Figure 2. Lifestyle Changes among the Subjects in 
the SOS Study over a 10-Year Period.



在整个试验中,手术组与对照组相比,能量摄取减少,而且积极进行身体锻炼的个体更多。
在继续随访的2年和10年中,手术组中受试者的糖尿病、高脂血症、低水平的HDL-c、高血压、高尿酸症等,与对照组相比,显示出明显的改善;但是治疗高胆固醇血症方面,对照组和手术组没有表现出不同。其次,手术组与对照组相比,糖尿病、高甘油三酯血症、高尿酸血症的发病率也明显降低;但是没有发现两组在高胆固醇血症、高血压的发病率上的不同。

Lars等人得出结论,与传统的治疗方法相比,肥胖外科手术似乎是一种可行的治疗重度肥胖的手段。肥胖手术治疗可以带来体重的持续下降,除了高胆固醇血症方面外,可以从基础水平上,改善生活方式,改善心血管、糖尿病的危险因素。

最后,文章还强调,并不是所有的肥胖相关的代谢因素都因为体重的持续下降得以改善,所以仍需要进行长期的观察和随访试验,已明确体重下降对于总体病死率和心肌梗死、脑梗、癌症的发病率的影响。

原始出处:

Sjöström L1, Lindroos AK, Peltonen M, Torgerson J, Bouchard C, Carlsson B, Dahlgren S, Larsson B, Narbro K, Sjöström CD, Sullivan M, Wedel H; Swedish Obese Subjects Study Scientific Group.Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery.N Engl J Med. 2004 Dec 23;351(26):2683-93.[pdf free]


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    2021-11-09 湘雅科教

    已拜读,受益匪浅。

    0

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    2015-06-08 ljjj1053

    好好学习学习

    0

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