幽门螺杆菌阳性患者介入术后三联根除治疗可减少消化道出血

2017-03-21 朱朱 中国循环杂志

新疆医科大学第一附属医院学者在我刊发文称,对于经皮冠状动脉介入术(PCI)后的患者,幽门螺杆菌(Hp)感染可增加抗血小板药物治疗的上消化道出血风险,如采取Hp根除治疗可显着降低出血风险。

新疆医科大学第一附属医院学者在我刊发文称,对于经皮冠状动脉介入术(PCI)后的患者,幽门螺杆菌(Hp)感染可增加抗血小板药物治疗的上消化道出血风险,如采取Hp根除治疗可显着降低出血风险。

该项回顾性研究显示,随访1年时,Hp阳性但未接受Hp根除治疗的患者(非治疗组)中上消化道出血率(5.2%)明显高于Hp阴性者(Hp阴性组,1.8%)、Hp阳性但接受Hp根除治疗的患者(治疗组,1.8%)。非治疗组的呕血+ 黑便以及黑便发生率(21.4%,57.1%)也均明显高于治疗组(0,14.3%)和Hp阴性组(0,20.0%)。非治疗组所有患者都有不同程度的贫血,而治疗组和Hp阴性组贫血发生率分别为57.1%和50%。

1年后,治疗组中82.4%的患者Hp检测已转为阴性,而非治疗组所有患者仍Hp阳性。

作者认为,PCI术后患者一旦确诊为Hp感染阳性,应立即给予抗Hp治疗,目前临床上以两种抗生素、质子泵抑制剂三联疗法比较常用。研究证实,奥美拉唑、阿莫西林、克拉霉素三联治疗方案对幽门螺杆菌清除效果良好,可有效降低上消化道出血的风险。

该研究选取在新疆医科大学第一附属医院行PCI的1 482例患者进行回顾性分析,根据患者术后14C尿素呼气试验结果,Hp阳性患者921例,Hp阴性患者561例(Hp阴性组);同时根据患者是否接受Hp根除治疗,将Hp阳性患者分为治疗组(387例)和非治疗组(534 例)。

原始出处:
刘静, 张铁亮, 戴远辉, 等. 幽门螺杆菌感染与经皮冠状动脉介入治疗术后抗血小板治疗诱发上消化道出血的关系. 中国循环杂志, 2016, 31: 1060-1063.

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    2017-10-18 kcb069
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    2017-06-16 风铃830
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    2017-03-28 jyzxjiangqin

    幽门螺杆菌阳性的研究。

    0

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  7. [GetPortalCommentsPageByObjectIdResponse(id=899371, encodeId=887b8993e1aa, content=<a href='/topic/show?id=2c8349102b0' target=_blank style='color:#2F92EE;'>#幽门螺杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49102, encryptionId=2c8349102b0, topicName=幽门螺杆菌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Nov 15 20:51:46 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811707, encodeId=b6521811e07d3, content=<a href='/topic/show?id=751f8889423' target=_blank style='color:#2F92EE;'>#螺杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88894, encryptionId=751f8889423, topicName=螺杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Wed Oct 18 09:13:00 CST 2017, time=2017-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027380, encodeId=5deb202e3802d, content=<a href='/topic/show?id=80e262286bf' target=_blank style='color:#2F92EE;'>#根除治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62286, encryptionId=80e262286bf, topicName=根除治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Tue Sep 05 09:13:00 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683640, encodeId=361d1683640c8, content=<a href='/topic/show?id=c2fc6228167' target=_blank style='color:#2F92EE;'>#根除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62281, encryptionId=c2fc6228167, topicName=根除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=07d627990740, createdName=风铃830, createdTime=Fri Jun 16 06:13:00 CST 2017, time=2017-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183178, encodeId=252d1831e8c2, content=幽门螺杆菌阳性的研究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue Mar 28 07:29:24 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464526, encodeId=d1541464526f7, content=<a href='/topic/show?id=32e765e6591' target=_blank style='color:#2F92EE;'>#消化道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65765, encryptionId=32e765e6591, topicName=消化道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7b6e6676048, createdName=changhe715, createdTime=Thu Mar 23 03:13:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181988, encodeId=01dc18198824, content=学习并收藏!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed Mar 22 20:15:31 CST 2017, time=2017-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181824, encodeId=32f218182434, content=好思路,术后需要服用阿斯匹林,易导致胃黏膜破损并出血,抗幽门螺杆菌可以降低风险!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=77711725691, createdName=doctor_hong, createdTime=Wed Mar 22 07:13:56 CST 2017, time=2017-03-22, status=1, ipAttribution=)]
    2017-03-22 大爰

    学习并收藏!!

    0

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    2017-03-22 doctor_hong

    好思路,术后需要服用阿斯匹林,易导致胃黏膜破损并出血,抗幽门螺杆菌可以降低风险!

    0

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