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JACC：脂蛋白水平能否预测女性心血管疾病发生风险？

2018-07-14 MedSci MedSci原创

心血管脂蛋白女性
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脂蛋白（a）[Lp(a)]虽然已证实与心血管疾病（CVD）的发生相关，但其对CVD的预测价值尚存在争议。本研究的目的旨在评估Lp(a)在女性CVD发生中的临床预测价值。本研究纳入了来自WHS临床研究中的24558名女性、WHI临床研究中的1815名女性、JUPITER临床研究中的2569名女性和5161名男性，通过浊度测定法对其进行了Lp(a)含量测定。分析结果显示，在WHS临床研究中，Lp(a)

脂蛋白（a）[Lp(a)]虽然已证实与心血管疾病（CVD）的发生相关，但其对CVD的预测价值尚存在争议。本研究的目的旨在评估Lp(a)在女性CVD发生中的临床预测价值。

本研究纳入了来自WHS临床研究中的24558名女性、WHI临床研究中的1815名女性、JUPITER临床研究中的2569名女性和5161名男性，通过浊度测定法对其进行了Lp(a)含量测定。分析结果显示，在WHS临床研究中，Lp(a) >50 mg/dl且总胆固醇水平>220 mg/dl的女性与CVD发生风险增加呈曲线相关，这种相关性也在WHI和JUPITER临床研究中的女性中得到了重复验证。另外，在JUPITER临床研究中的男性，Lp(a)水平与CVD发生风险呈强相关，即使胆固醇水平较低。

本研究结果显示，脂蛋白（a）水平仅在总胆固醇高的女性中与心血管疾病的发生风险相关。

原始出处：

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    2018-08-02 hbwxf

    #JACC#

    0

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    2018-07-31 wmw990556

    学习了，，，

    0

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    2018-07-18 1e0f8808m18(暂无匿称)

    学习了谢谢分享

    0

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    2018-07-17 1e0f8808m18(暂无匿称)

    学习学习.谢谢分享!

    0

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    2018-07-16 12498568m50暂无昵称

    #ACC#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1854089, encodeId=5f7a18540890c, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Thu Aug 02 00:04:00 CST 2018, time=2018-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335275, encodeId=be733352e533, content=学习了，，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7miblj4EHgFns3Mic85NWcRwwHYXCBDA8jW0GZ6iaZT55p0bicOcZXvsdT9henNafvCibicOUcwJtWUmkw/0, createdBy=a1fe1637734, createdName=wmw990556, createdTime=Tue Jul 31 08:39:35 CST 2018, time=2018-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332339, encodeId=ef9833233961, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Jul 18 00:16:22 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332111, encodeId=a20d33211154, content=学习学习.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Tue Jul 17 00:15:19 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325892, encodeId=bbf81325892b2, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Mon Jul 16 07:04:00 CST 2018, time=2018-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424711, encodeId=10e61424e1142, content=<a href='/topic/show?id=5a3b8441438' target=_blank style='color:#2F92EE;'>#脂蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84414, encryptionId=5a3b8441438, topicName=脂蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23ea3924919, createdName=juliusluan79, createdTime=Mon Jul 16 07:04:00 CST 2018, time=2018-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498443, encodeId=4f58149844326, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Mon Jul 16 07:04:00 CST 2018, time=2018-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331804, encodeId=0ad833180417, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jul 15 14:15:19 CST 2018, time=2018-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331712, encodeId=1201331e1229, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Sun Jul 15 08:09:22 CST 2018, time=2018-07-15, status=1, ipAttribution=)]
    2018-07-16 juliusluan79

    #脂蛋白#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1854089, encodeId=5f7a18540890c, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Thu Aug 02 00:04:00 CST 2018, time=2018-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335275, encodeId=be733352e533, content=学习了，，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7miblj4EHgFns3Mic85NWcRwwHYXCBDA8jW0GZ6iaZT55p0bicOcZXvsdT9henNafvCibicOUcwJtWUmkw/0, createdBy=a1fe1637734, createdName=wmw990556, createdTime=Tue Jul 31 08:39:35 CST 2018, time=2018-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332339, encodeId=ef9833233961, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Jul 18 00:16:22 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332111, encodeId=a20d33211154, content=学习学习.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Tue Jul 17 00:15:19 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325892, encodeId=bbf81325892b2, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Mon Jul 16 07:04:00 CST 2018, time=2018-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424711, encodeId=10e61424e1142, content=<a href='/topic/show?id=5a3b8441438' target=_blank style='color:#2F92EE;'>#脂蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84414, encryptionId=5a3b8441438, topicName=脂蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23ea3924919, createdName=juliusluan79, createdTime=Mon Jul 16 07:04:00 CST 2018, time=2018-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498443, encodeId=4f58149844326, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Mon Jul 16 07:04:00 CST 2018, time=2018-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331804, encodeId=0ad833180417, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jul 15 14:15:19 CST 2018, time=2018-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331712, encodeId=1201331e1229, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Sun Jul 15 08:09:22 CST 2018, time=2018-07-15, status=1, ipAttribution=)]
    2018-07-16 andy2090

    #血管疾病#

    0

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    2018-07-15 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2018-07-15 smartxiuxiu

    好

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