JAHA:左心房容积和功能与缺血性卒中长期发生率的关系

2022-09-10 MedSci原创 MedSci原创

经胸超声心动图测量的低LA排空分数与未来的缺血性卒中相关,且独立于房颤的发生。

缺血性卒中是世界范围内致残和死亡的主要原因。新出现的证据表明左心房(LA)结构、机械和电异常与缺血性卒中风险增加之间存在关联。一般人群的左房容积和排空分数可能涉及心房心肌病的结构和功能,在没有房颤或卒中的情况下,其与缺血性卒中的长期风险相关。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员探究了LA体积和功能与缺血性卒中之间的关系。

在一个社区队列中,研究人员通过经胸超声心动图测量了左心房最小容积、左心房最大容积和左心房排空分数。该研究的主要终点为缺血性卒中。研究人员排除了已知房颤或既往缺血性卒中的参与者。

研究人员共纳入了1866名参与者。平均年龄为58±16岁,57%为女性。在中位随访16.5年(四分位数范围为11.4-16.8年)期间,共发生176例(9.4%)缺血性卒中。在以死亡为竞争风险的多变量原因特定回归模型和竞争风险模型中,LA排空分数与缺血性卒中相关(每减少10%的风险比[HR]为1.14[95%CI为1.02-1.28])和(亚分布HR为1.14[95%CI为1.01-1.29])。当对随访期间发生房颤的参与者进行调整时,这种相关性仍然存在(每降低10%的HR为1.12[95%CI为1.00-1.26])。在相同的模型中,LA体积与缺血性卒中无关。LA排空分数和LA体积与全因死亡率无关。

由此可见,经胸超声心动图测量的低LA排空分数与未来的缺血性卒中相关,且独立于房颤的发生。

原始出处:

Bjørn Strøier Larsen.et al.Left Atrial Volumes and Function, and Long‐Term Incidence of Ischemic Stroke in the General Population.JAHA.2022.https://www.ahajournals.org/doi/10.1161/JAHA.122.027031

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    2023-02-01 ylz8411
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    2022-09-11 zhaohui6731
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    2022-09-11 sodoo

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