PLoS One:荟萃分析显示年轻的类风湿关节炎患者心血管疾病的风险**

2016-06-29 phylis 译 MedSci原创

背景:类风湿性关节炎(RA)患者心血管疾病(CVD)的发病率增加。类风湿性关节炎是否增加心血管(CVD)的风险目前还不清楚,尤其是在女性和年轻的类风湿关节炎患者。在本研究中,研究者使用直接比较研究的荟萃分析,旨在分析,相对于一般人群,RA患者年龄和性别对心血管风险的影响。方法:系统性文献检索MEDLINE数据库中报告RA和一般人群对CV事件发生影响的文献,按照性别或年龄分层。应用渥太华纽卡斯尔量表

背景:类风湿性关节炎(RA)患者心血管疾病(CVD)的发病率增加。类风湿性关节炎是否增加心血管(CVD)的风险目前还不清楚,尤其是在女性和年轻的类风湿关节炎患者。在本研究中,研究者使用直接比较研究的荟萃分析,旨在分析,相对于一般人群,RA患者年龄和性别对心血管风险的影响。

方法:系统性文献检索MEDLINE数据库中报告RA和一般人群对CV事件发生影响的文献,按照性别或年龄分层。应用渥太华纽卡斯尔量表评估质量。应用逆方差方法对荟萃分析进行RR分析。

结果:共搜索出1372个记录,筛选后共包括13项研究。类风湿性关节炎的女性和男性发生卒中的风险较高,RR值分别为1.35(1.30-1.40),1.31(1.21-1.43);女性和男性冠状动脉疾病发生风险较高,RR 分别为1.65(1.54-1.76),RR 1.55((1.41-1.69);女性和男性心血管疾病发生的RR 为1.56(1.49-1.62)和1.50(1.41-1.60)。与一般人群相比,年轻的患者心血管事件发生率最高RR 2.59(1.77-3.79),而老年患者具有最低的相对风险RR 1.27 (1.16-1.38)。

结论:RA患者发生CVD的相对危险的呈年龄依赖性,但不依赖于性别:男性和女性的心血管疾病的相对风险相似,而年轻的类风湿性关节炎患者(50岁)相对危险度最高,老年患者的相对风险最低。

原始出处:

Fransen J, Kazemi-Bajestani SM, et al. Rheumatoid Arthritis Disadvantages Younger Patients for Cardiovascular Diseases: A Meta-Analysis. PLoS One. 2016 Jun 16.


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    2017-05-10 venlin
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498019, encodeId=a2cc149801962, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Fri Jul 01 13:10:00 CST 2016, time=2016-07-01, status=1, ipAttribution=)]
    2016-09-14 ylzr123

    赞了!深度好文,深入学习。

    0

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498019, encodeId=a2cc149801962, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Fri Jul 01 13:10:00 CST 2016, time=2016-07-01, status=1, ipAttribution=)]
    2016-07-10 oo902

    类风湿关节炎又和心脏病扯到一块了

    0

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498019, encodeId=a2cc149801962, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Fri Jul 01 13:10:00 CST 2016, time=2016-07-01, status=1, ipAttribution=)]
    2016-07-02 午夜星河

    应该好好看看

    0

  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498019, encodeId=a2cc149801962, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Fri Jul 01 13:10:00 CST 2016, time=2016-07-01, status=1, ipAttribution=)]
    2016-07-01 lmm397
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