J Renal Inj Prev:肾功能正常的冠状动脉造影患者中的造影剂诱发的肾病

2020-03-02 不详 网络

尽管造影剂诱发的肾病(CIN)是潜在肾功能不全患者中放射性造影剂给药的众所周知的并发症,但是肾功能正常的患者中有关CIN的研究很少且这些患者中CIN诊断结果欠佳。本研究旨在评估接受冠状动脉造影的肾功能正常的糖尿病和非糖尿病患者的CIN。这项横断面和前瞻性研究于2010年10月至2011年2月在伊朗阿瓦兹的伊玛目医院对具有正常肾功能的候选患者进行了诊断性冠状动脉造影。CIN定义为血清肌酐(sCr)增

尽管造影剂诱发的肾病(CIN)是潜在肾功能不全患者中放射性造影剂给药的众所周知的并发症,但是肾功能正常的患者中有关CIN的研究很少且这些患者中CIN诊断结果欠佳。本研究旨在评估接受冠状动脉造影的肾功能正常的糖尿病和非糖尿病患者的CIN。

这项横断面和前瞻性研究于2010年10月至2011年2月在伊朗阿瓦兹的伊玛目医院对具有正常肾功能的候选患者进行了诊断性冠状动脉造影。CIN定义为血清肌酐(sCr)增加>对比剂给药两天后为0.5 mg / dL。使用标准化的调查表收集人口统计学,临床和实验室数据。

研究共纳入254例患者(男性140例,女性114例,平均年龄56.6±11.9岁)。其中,充血性心力衰竭(CHF)60例(23.6%),糖尿病(DM)57例(22.4%)。男性和女性在对比剂给药前的平均sCr水平分别为1.05±0.22和0.93±0.17 mg/dL。27例患者发生CIN(10.6%),男女之间(P = 0.386)以及有或没有CHF(P = 0.766)的患者无差异。在CIN和DM(P = 0.001)与平均造影剂量(P = 0.001)之间存在显著相关性。

总之,尽管CIN是接受冠状动脉造影的糖尿病肾病患者的常见问题,但无糖尿病肾病的糖尿病患者以及肾功能正常的无DM的患者也有造影剂肾病的发生风险。

原始出处:

Ahmadreza Assareh, 1 Saeed Yazdankhah, et al., Contrast induced nephropathy among patients with normal renal function undergoing coronary angiography. J Renal Inj Prev. 2016; 5(1): 21–24. doi: 10.15171/jrip.2016.05

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    2021-02-09 yese
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    2020-04-10 jml2020
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    2020-03-03 sodoo
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    2020-03-02 飛歌

    学习了,很有用,不错

    0