JACC:心肌梗死后心衰的患者,癌症风险更高

2016-07-12 Seven L 译 MedSci原创

根据美国心脏病学院杂志发表的研究数据显示,心肌梗死后发生心衰的患者,患癌症的风险增加了。梅奥医疗保健科的Veronique L. Roger博士和同事分析了1081例明尼苏达心肌梗死患者的数据,在平均4.9年时间里随访了5327人年。在研究期间,228例(21%)心肌梗死患者发展为心衰,98例发生癌症,不包括非黑色素瘤皮肤癌。中位数诊断为心衰的时间为3天;心衰患者的癌症发病率密度率33.7/100

美国心脏病学院杂志发表的研究数据显示,心肌梗死后发生心衰的患者,患癌症的风险增加了。

梅奥医疗保健科的Veronique L. Roger博士和同事分析了1081例明尼苏达心肌梗死患者的数据,在平均4.9年时间里随访了5327人年。

在研究期间,228例(21%)心肌梗死患者发展为心衰,98例发生癌症,不包括非黑色素瘤皮肤癌。中位数诊断为心衰的时间为3天;心衰患者的癌症发病率密度率33.7/1000人年,而没有心衰的患者该数据为15.6/1000人年(P = .0002)。

据研究表明,未校正时,心衰患者的癌症风险为HR = 2.16, 95% CI, 1.39-3.35;对年龄、性别和Charlson合并症指数校正后,HR=1.71; 95% CI, 1.07-2.73。

非心衰患者的癌症死亡率HR=4.9 (95% CI, 3.1-7.74);而心衰患者该数据为HR=3.91 (95% CI, 1.88-8.12)(交互作用P= .76)。

Roger和同事写道:“心衰和癌症之间的联系可能与特定药物有关,比如血管紧张素受体拮抗剂、强心苷、利尿剂、他汀类药物和普拉格雷等。”

原始出处:


Hasin T, et al. HEART FAILURE AFTER MYOCARDIAL INFARCTION IS ASSOCIATED WITH INCREASED RISK OF CANCER.J Am Coll Cardiol. 2016;doi:10.1016/j.jacc.2016.04.053.

Patients with HF after MI at elevated risk for cancer.Healio.July 11, 2016


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  1. [GetPortalCommentsPageByObjectIdResponse(id=1853550, encodeId=d6f81853550b8, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Sep 24 13:46:00 CST 2016, time=2016-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=122088, encodeId=2d3412208805, content=己拜读,受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 11 08:56:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93161, encodeId=4942931610e, content=心梗后心衰的患者,预期寿命本来就低,这个研究很创新,但意义有限, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Jul 16 07:40:00 CST 2016, time=2016-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93104, encodeId=09ed93104fe, content=不错哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Thu Jul 14 18:32:00 CST 2016, time=2016-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325266, encodeId=28221325266da, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Jul 14 03:46:00 CST 2016, time=2016-07-14, status=1, ipAttribution=)]
    2016-09-24 hbwxf
  2. [GetPortalCommentsPageByObjectIdResponse(id=1853550, encodeId=d6f81853550b8, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Sep 24 13:46:00 CST 2016, time=2016-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=122088, encodeId=2d3412208805, content=己拜读,受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 11 08:56:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93161, encodeId=4942931610e, content=心梗后心衰的患者,预期寿命本来就低,这个研究很创新,但意义有限, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Jul 16 07:40:00 CST 2016, time=2016-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93104, encodeId=09ed93104fe, content=不错哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Thu Jul 14 18:32:00 CST 2016, time=2016-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325266, encodeId=28221325266da, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Jul 14 03:46:00 CST 2016, time=2016-07-14, status=1, ipAttribution=)]
    2016-09-11 1e10c84am36(暂无匿称)

    己拜读,受益匪浅

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1853550, encodeId=d6f81853550b8, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Sep 24 13:46:00 CST 2016, time=2016-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=122088, encodeId=2d3412208805, content=己拜读,受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 11 08:56:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93161, encodeId=4942931610e, content=心梗后心衰的患者,预期寿命本来就低,这个研究很创新,但意义有限, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Jul 16 07:40:00 CST 2016, time=2016-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93104, encodeId=09ed93104fe, content=不错哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Thu Jul 14 18:32:00 CST 2016, time=2016-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325266, encodeId=28221325266da, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Jul 14 03:46:00 CST 2016, time=2016-07-14, status=1, ipAttribution=)]
    2016-07-16 oo902

    心梗后心衰的患者,预期寿命本来就低,这个研究很创新,但意义有限

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1853550, encodeId=d6f81853550b8, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Sep 24 13:46:00 CST 2016, time=2016-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=122088, encodeId=2d3412208805, content=己拜读,受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 11 08:56:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93161, encodeId=4942931610e, content=心梗后心衰的患者,预期寿命本来就低,这个研究很创新,但意义有限, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Jul 16 07:40:00 CST 2016, time=2016-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93104, encodeId=09ed93104fe, content=不错哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Thu Jul 14 18:32:00 CST 2016, time=2016-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325266, encodeId=28221325266da, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Jul 14 03:46:00 CST 2016, time=2016-07-14, status=1, ipAttribution=)]
    2016-07-14 owlhealth

    不错哦

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1853550, encodeId=d6f81853550b8, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Sep 24 13:46:00 CST 2016, time=2016-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=122088, encodeId=2d3412208805, content=己拜读,受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 11 08:56:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93161, encodeId=4942931610e, content=心梗后心衰的患者,预期寿命本来就低,这个研究很创新,但意义有限, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Jul 16 07:40:00 CST 2016, time=2016-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93104, encodeId=09ed93104fe, content=不错哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Thu Jul 14 18:32:00 CST 2016, time=2016-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325266, encodeId=28221325266da, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Jul 14 03:46:00 CST 2016, time=2016-07-14, status=1, ipAttribution=)]

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