JACC:正常水平内高敏肌钙蛋白越高,胸痛患者心梗风险越高

2019-01-23 MedSci MedSci原创

由于心血管危险因素的多样性,评估门诊胸痛的病人是否有冠心病(CAD)是一件比较困难的事情。本研究的目的旨在评估正常水平高敏肌钙蛋白(hsTnI)单分子水平上的计数对门诊胸痛患者的诊断价值。本研究纳入了PROMISE 临床研究中留有血样本的患者,并对其hsTnI水平进行了分析,主要终点事件是1年后的死亡、急性心梗或因不稳定心绞痛住院,次要终点事件是心源性死亡或急性心梗的复合事件。最终,共纳入分析了4

由于血管危险因素的多样性,评估门诊胸痛的病人是否有冠心病(CAD)是一件比较困难的事情。本研究的目的旨在评估正常水平高敏肌钙蛋白(hsTnI)单分子水平上的计数对门诊胸痛患者的诊断价值。

本研究纳入了PROMISE 临床研究中留有血样本的患者,并对其hsTnI水平进行了分析,主要终点事件是1年后的死亡、急性心梗或因不稳定心绞痛住院,次要终点事件是心源性死亡或急性心梗的复合事件。最终,共纳入分析了4021名患者,平均hsTnI水平是 1.6 ng/l,hsTnI水平越高,主要终点事件的发生风险越高。在多元回归模型中,hsTnI水平与死亡、急性心梗或因不稳定心绞痛住院风险呈独立相关性(HR:1.54; p < 0.001),与心源性死亡也呈独立相关性(HR:1.52 ; p < 0.001),尤其是近期不良事件的发生风险。

研究结果显示,对于胸痛疑似冠心病的门诊病人,即使高敏肌钙蛋白在正常水平内,高敏肌钙蛋白越高,近期的死亡、急性心梗和住院的风险更高。

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    2019-02-19 hbwxf
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    2019-01-26 wxl882001

    了解一下

    0

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