Brit J Cancer:腰围、臀围……这些都暗示你的患癌风险!

2017-05-27 MedSci 转化医学网

根据英国癌症杂志(British Journal of Cancer)最新刊载的一项研究报告,身体周围脂肪可能与身体质量指数(BMI)一样影响着人们癌症的疾病的具体风险。

根据英国癌症杂志(British Journal of Cancer)最新刊载的一项研究报告,身体周围脂肪可能与身体质量指数(BMI)一样影响着人们癌症的疾病的具体风险。

这项研究表明,人们的腰围每增加约11cm,肥胖相关癌症的发病风险就会增加13%。臀围每增加8cm,结直肠癌的发病风险就会增加15%。

除此之外,过多的身体脂肪还会影响人们的性激素水平,如雌激素和睾丸激素等。过多的身体脂肪在一定程度上能够导致人们血液胰岛素水平的上升并进而导致炎症。所有这些肥胖相关症状都与癌症风险的增加密切相关。

基于最新的肥胖相关癌症比较标准方法,研究人员对数万名成人的各项身体治疗进行了测量与研究。国际癌症研究机构IARC(WHO 下属的国际癌症研究中心, 全称为 International Agency for Research on Cancer)的科学家们表示,人们的身体尺寸,BMI,腰围和腰臀比的三种不同测量结果都可以预测了人们老年时发生肥胖相关癌症的风险。

该研究总共整合了约43,000名参与者的健康数据,在为期均12年的跟踪研究中,被观察者中共有1600多人被诊断为肥胖相关癌症。

研究对应文章的主要作者,IARC首席科学家Heinz Freisling博士说:“我们的研究结果表明,身体脂肪与体重指数一样,都可以作为评估人们肥胖相关癌症发病风险的良好指标。具体来说,腰部周围脂肪对于某些癌症非常重要,而臀部周围脂肪又与另一些癌症的高发存在明显关联。虽然我们的研究体现了这一现象,但仍然需要进一步的研究以具体阐明这一现象存在的背后原因。”

“为了更好体现人们的生物学基础,我们认为在研究癌症发病风险时,不仅要考虑到人们的具体BMI,还需要考虑道人们的体型与脂肪沉积区域对于癌症发病的影响。”文章的作者补充道。

根据既有的相关研究,超重或肥胖是位列吸烟之后的最大单一可预防癌症诱因,与13种类型的癌症(包括肠,乳腺癌胰腺癌)密切相关。

英国癌症领域的专家Julie Sharp博士说:“这项研究再次强调了超重或肥胖对诸如乳腺癌和肠癌等癌症的重要影响。”

“这项研究最重要的意义是要让人们了解到了如何减少癌症的发病风险,虽然不能做出任何具体的担保,但保持健康的体重和脂肪率确实可以帮助你维护健康。”文章的作者总结道。

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    2017-06-04 flysky120

    学习一下知识

    0

  3. 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    2017-05-31 大爰

    学习了谢谢分享!!

    0

  4. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Ne59unJiaEKVBVsw2H5iaLnmLt108lIrJ6YTqVphNiao7iaUJuuRE3xickhLErmQ99C3vF1zsf7DKXibuAQLOMjy7cgqj/0, createdBy=a8102049538, createdName=Medsci0421, createdTime=Sat May 27 14:40:59 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2017-05-29 naiwu77
  5. 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  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Ne59unJiaEKVBVsw2H5iaLnmLt108lIrJ6YTqVphNiao7iaUJuuRE3xickhLErmQ99C3vF1zsf7DKXibuAQLOMjy7cgqj/0, createdBy=a8102049538, createdName=Medsci0421, createdTime=Sat May 27 14:40:59 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2017-05-29 lq0307
  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Ne59unJiaEKVBVsw2H5iaLnmLt108lIrJ6YTqVphNiao7iaUJuuRE3xickhLErmQ99C3vF1zsf7DKXibuAQLOMjy7cgqj/0, createdBy=a8102049538, createdName=Medsci0421, createdTime=Sat May 27 14:40:59 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2017-05-28 luominglian113

    学习了谢谢分享,肥胖是危险因素

    0

  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Ne59unJiaEKVBVsw2H5iaLnmLt108lIrJ6YTqVphNiao7iaUJuuRE3xickhLErmQ99C3vF1zsf7DKXibuAQLOMjy7cgqj/0, createdBy=a8102049538, createdName=Medsci0421, createdTime=Sat May 27 14:40:59 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2017-05-28 doctorJiangchao

    继续学习。

    0

  9. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Ne59unJiaEKVBVsw2H5iaLnmLt108lIrJ6YTqVphNiao7iaUJuuRE3xickhLErmQ99C3vF1zsf7DKXibuAQLOMjy7cgqj/0, createdBy=a8102049538, createdName=Medsci0421, createdTime=Sat May 27 14:40:59 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2017-05-27 天涯183

    非常好的文章,学习啦,很受益。

    0

  10. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Ne59unJiaEKVBVsw2H5iaLnmLt108lIrJ6YTqVphNiao7iaUJuuRE3xickhLErmQ99C3vF1zsf7DKXibuAQLOMjy7cgqj/0, createdBy=a8102049538, createdName=Medsci0421, createdTime=Sat May 27 14:40:59 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2017-05-27 Medsci0421

    不能胖

    0

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癌症虽然是一种极其复杂的疾病,但是它的定义却相当简单,那就是异常和不可控的细胞的增长。罗彻斯特大学RNA生物学中心的研究人员们已经确定了一种减缓癌细胞疯长的新科技,这种方法适用于所有类型的癌症。报告结果发表于今天的《科学》杂志上,此次研究由美国国立卫生研究院资助。虽然还有很长一段路要走,但是这一科技无疑为今后的治疗指明了方向。

PNAS:当癌症来敲门,结构生物学不是稻草而是救生器材

癌症降临,身体中的许多细胞都已经出现了问题。找出癌症的关键,才能捋清事实,指引出路。基因开关正是这团乱麻般的细胞变异的核心。“人类许多疾病的产生都是由于基因开关发生了故障,”加州理工大学传统医学研究所研究员André Hoelz说。“在原子层面阐明它们的工作机理,才能让我们看清如何定制药物可使它们失活,在许多情况下,这是走向治愈的关键步骤。”急性髓系白血病(AML)是一种极具攻击性的癌症,有一个基

Science:让所有类型癌细胞都减缓生长的方法

5月26日的Science上发表了Rochester大学研究人员发现的一种新方法,可以减缓所有类型癌症细胞的快速生长特征。该方法通过靶向Tudor-SN蛋白能够抑制快速增长的癌细胞,已经在实验室中进行了肾癌和宫颈癌细胞的研究。

Nat Commun:你不经意的饮食习惯可能正在“喂养”癌细胞

在一项新的研究中,来自德克萨斯大学的科学家们发现,某些类型的癌症患者比其他人更喜欢吃甜食。长久以来,科学界一直怀疑某些癌细胞需要依靠糖分作为它们的能量来源,此次事实证明,一个特定细胞癌—鳞状细胞癌对糖分最依赖。完整的研究报告发表与5月26日《自然通讯》在线期刊上。