JAHA:血浆总胆红素与高血压相关性研究

2017-11-13 MedSci MedSci原创

循环血液中的总胆红素水平与心血管疾病发生风险的升高呈独立相关性。然而,循环血液中的总胆红素水平与高血压的关系尚未阐明。本研究纳入了PREVEND临床试验中的3989名无高血压的研究对象,并对其基线的血浆总胆红素水平进行了检测。结果发现,经过平均10.7年时间的随访,共有1206名新发的高血压患者,并且基线的血浆总胆红素水平与高血压发生的风险基本呈对数相关性,血浆总胆红素的log值每升高一个SD,年

循环血液中的总胆红素水平与心血管疾病发生风险的升高呈独立相关性。然而,循环血液中的总胆红素水平与高血压的关系尚未阐明。本研究纳入了PREVEND临床试验中的3989名无高血压的研究对象,并对其基线的血浆总胆红素水平进行了检测。结果发现,经过平均10.7年时间的随访,共有1206名新发的高血压患者,并且基线的血浆总胆红素水平与高血压发生的风险基本呈对数相关性,血浆总胆红素的log值每升高一个SD,年龄和性别调整后的HR值为0.86(0.81-0.92; P<0.001),经其他已有的危险因素调整后HR值变为0.94 (0.88-0.99; P=0.040)。此外,UGT1A1*28位点的一个变异(rs6742078)与血浆总胆红素水平呈强相关性,但与血压或者高血压无明显相关性(P>0.05),这使得血浆总胆红素与高血压的关系变得更有争议。研究结果显示,血浆总胆红素与高血压发生风险的相关性仍存在争议,需进一步研究验证。原始出处:Setor K et al.Circulating Total Bilirubin and Future Risk of Hypertension in

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    2017-11-24 changjiu

    学习一下谢谢

    0

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    2017-11-16 changjiu

    谢谢学习一下

    0

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    2017-11-15 1e145228m78(暂无匿称)

    学习了谢谢作者分享!

    0

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    2017-11-15 zhaohui6731
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    2017-11-13 中医痴

    不错了.学习了.谢谢分享!

    0

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    2017-11-13 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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