Intens Care Med:感染性休克左室收缩功能障碍!

2017-04-09 xing.T MedSci原创

在大多数感染性休克患者中斑点追踪衍生的应变减少,揭示了隐匿性脓毒性心肌功能障碍,但其可行性较差。研究人员发现大部分的收缩性能指标与后负荷指数之间呈负相关。准确的后负荷评估在感染性休克患者左室收缩功能的充足解释中至关重要。

脓毒性心肌功能障碍的临床意义是有争议的。许多指标可能在归纳感染性休克心脏功能的特征时是有用的,但在临床上其可行性和生理连贯性仍是未知。近日,危重病医学领域权威杂志Intensive Care Medicine上针对这一问题发表了一篇研究文章。

研究人员在感染性休克患者前3天通过组织多普勒和斑点追踪前瞻性地记录了患者血流动力学指标和超声心动图数据。机能减退、机能正常和机能亢进分别被定义为左室射血分数(LVEF)<45%,45-60%和>60%。研究人员测量和分析了12个评估心脏收缩性和负荷条件的血流动力学指标。

研究人员对132例患者共进行了297超声心动图检查。在第一个24小时内(H1-24),48名(36.4%)患者表现为机能亢进,55名(41.7%)患者机能正常,以及29名(22%)患者机能减退。有13名患者出现继发性机能减退,在H1-24不存在,但在H25-48或H49-72出现,在前3天内,总的发生有42名(31.8%)。尽管有限的可行性(<50%),评估的大多数(约70%)患者整体LV纵向峰值收缩应变受损,包括所有那些LVEF下降以及早期下降LVEF继发性恶化的患有。大部分的收缩性能指标与后负荷指数呈负相关。机能亢进的患者在后负荷指数上表现出最严重的降低。LV机能亢进的患者医院死亡率明显高于其对照患者:30(62.5%)vs. 35(41.7%),P=0.02。

在大多数感染性休克患者中斑点追踪衍生的应变减少,揭示了隐匿性脓毒性心肌功能障碍,但其可行性较差。研究人员发现大部分的收缩性能指标与后负荷指数之间呈负相关。准确的后负荷评估在感染性休克患者左室收缩功能的充足解释中至关重要。

原始出处:

Florence Boissier, et al. Left ventricular systolic dysfunction during septic shock: the role of loading conditions.Intensive Care Medicine.2017. http://icmjournal.esicm.org/journals/abstract.html?v=43&j=134&i=5&a=4698_10.1007_s00134-017-4698-z&doi=

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    2017-04-10 tofsw

    学习了谢谢分享

    0

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    2017-04-09 九九消寒

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