NEJM:绦虫癌细胞可传染给人并使人患癌症

2015-11-06 QQduhq 译 MedSci原创

CDC宣布发现了一例寄生虫癌细胞传染给人类宿主并在宿主体内造成癌状肿瘤的病例,这是世界上首次发现寄生虫会把癌症传染给人。IDPB的研究人员对一位特殊的癌样肿瘤患者进行探究,她们发现,病人的肿瘤内部长有绦虫(短膜壳绦虫)。经过深入研究,Atis Muehlenbachs博士认为,若有癌症的绦虫在人们体内生长并且扩散并造成其他人的感染,则会使人易得癌症。这个研究结果发表在《新英格兰医学杂志》上。 这个

CDC宣布发现了一例寄生虫癌细胞传染给人类宿主并在宿主体内造成癌状肿瘤的病例,这是世界上首次发现寄生虫会把癌症传染给人。


IDPB的研究人员对一位特殊的癌样肿瘤患者进行探究,她们发现,病人的肿瘤内部长有绦虫(短膜壳绦虫)。经过深入研究,Atis Muehlenbachs博士认为,若有癌症的绦虫在人们体内生长并且扩散并造成其他人的感染,则会使人易得癌症。这个研究结果发表在《新英格兰医学杂志》上。
 
这个故事开始于2013年,地点位于在哥伦比亚。当地医生发现,一位41岁的艾滋病毒阳性患者在肺和淋巴结等处出现了异常的肿瘤细胞。医疗机构对于活检结果也无法下确切结论。肿瘤细胞看起来与癌细胞无异,但他们都没有遇到过这样的肿瘤细胞。这些细胞像普通癌细胞一样迅速增加,且局限于小范围内。但是,相比之下,这些细胞中的每一个细胞都小于人类标准的癌症细胞的1/10,有一些甚至彼此融合,这对人类肿瘤细胞而言是十分罕见的。基于种种疑点,哥伦比亚医疗团队将这些罕见的肿瘤样本送到CDC以便进行进一步调查。 

IDPB花费了大量的时间对这些细胞的来源及发展进行了详细的探究。 最终,他们发现了H. nana(短膜壳绦虫)的DNA。遗憾的是,72小时后病人死亡。 研究人员认为,一种名为短膜壳绦虫的寄生虫把癌细胞传染给他,并在他体内造成癌状肿瘤。

H. nana也被称为矮绦虫,大多长约40毫米,宽1毫米。在温带地区尤为常见,多生活在污染和不洁净的水中。目前已知,约3000种绦虫使用动物作为宿主,H. nana是全球最常见的感染人类患病的绦虫类型,且是仅知的可在人类小肠中完成整个生命周期的绦虫。

绦虫进入人类宿主是采用怎样的方式呢?

据调查,当人类的食物被啮齿类动物的粪便和昆虫污染,便可使得绦虫进入人体,最常见的是接触另一个感染者的粪便便可导致绦虫进入人体。全世界约有750万人感染H. Nana。由于受感染者临床体征不明显,所以往往将绦虫传染给其他人后都察觉不到。受感染者的主要临床表现是虚弱、乏力、厌食、头痛、腹泻和腹痛。

原始出处:

Muehlenbachs A, Bhatnagar J,et al.Malignant Transformation of Hymenolepis nana in a Human Host. N Engl J Med. 2015 Nov 5;373(19):1845-52.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=44023, encodeId=8f6f4402322, content=这个患者是HIV阳性,免疫缺陷才起病吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/icGe6hKLzrzFUGw2q3ZtkcGm8REfuskyuvibBDNkkYwwSNeZvTE08CDaELdy2BKJFEBWwXU7nqSKcias4vawgkPXQ/132, createdBy=0d661665562, createdName=sonyuan, createdTime=Sat Nov 28 16:09:00 CST 2015, time=2015-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42838, encodeId=65e9428384f, content=这也太恐怖了吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb9a1661810, createdName=1ddeea37m96(暂无匿称), createdTime=Sun Nov 08 14:24:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252056, encodeId=8dcd125205675, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sun Nov 08 13:18:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601364, encodeId=bb30160136405, content=<a href='/topic/show?id=5baa5299111' target=_blank style='color:#2F92EE;'>#患癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52991, encryptionId=5baa5299111, topicName=患癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=888f18872716, createdName=lq0307, createdTime=Sun Nov 08 13:18:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625387, encodeId=f7db162538e29, content=<a href='/topic/show?id=758fe895640' target=_blank style='color:#2F92EE;'>#绦虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78956, encryptionId=758fe895640, topicName=绦虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b0620746103, createdName=zhang92567, createdTime=Sun Nov 08 13:18:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42754, encodeId=140f42e54fa, content=太可怕了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=103e1661722, createdName=1ddee5aam97(暂无匿称), createdTime=Sat Nov 07 18:13:00 CST 2015, time=2015-11-07, status=1, ipAttribution=)]
    2015-11-28 sonyuan

    这个患者是HIV阳性,免疫缺陷才起病吧

    0

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    2015-11-08 1ddeea37m96(暂无匿称)

    这也太恐怖了吧

    0

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    2015-11-08 yxch36
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    2015-11-08 lq0307
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    2015-11-08 zhang92567
  6. [GetPortalCommentsPageByObjectIdResponse(id=44023, encodeId=8f6f4402322, content=这个患者是HIV阳性,免疫缺陷才起病吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/icGe6hKLzrzFUGw2q3ZtkcGm8REfuskyuvibBDNkkYwwSNeZvTE08CDaELdy2BKJFEBWwXU7nqSKcias4vawgkPXQ/132, createdBy=0d661665562, createdName=sonyuan, createdTime=Sat Nov 28 16:09:00 CST 2015, time=2015-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42838, encodeId=65e9428384f, content=这也太恐怖了吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb9a1661810, createdName=1ddeea37m96(暂无匿称), createdTime=Sun Nov 08 14:24:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252056, encodeId=8dcd125205675, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sun Nov 08 13:18:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601364, encodeId=bb30160136405, content=<a href='/topic/show?id=5baa5299111' target=_blank style='color:#2F92EE;'>#患癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52991, encryptionId=5baa5299111, topicName=患癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=888f18872716, createdName=lq0307, createdTime=Sun Nov 08 13:18:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625387, encodeId=f7db162538e29, content=<a href='/topic/show?id=758fe895640' target=_blank style='color:#2F92EE;'>#绦虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78956, encryptionId=758fe895640, topicName=绦虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b0620746103, createdName=zhang92567, createdTime=Sun Nov 08 13:18:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42754, encodeId=140f42e54fa, content=太可怕了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=103e1661722, createdName=1ddee5aam97(暂无匿称), createdTime=Sat Nov 07 18:13:00 CST 2015, time=2015-11-07, status=1, ipAttribution=)]
    2015-11-07 1ddee5aam97(暂无匿称)

    太可怕了

    0

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