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JCI Insight：揭秘机体坏死性软组织感染发生之谜

2016-07-11 佚名 生物谷

坏死性软组织
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甲型链球菌可以引发危及生命的坏死性筋膜炎，随后其会快速扩散并且破坏机体的软组织，通常治疗甲型链球菌引发的坏死性软组织感染的疗法需要强化治疗，同时进行手术干预；该疾病通常会导致受影响的肢体被截肢。近日一项刊登于国际杂志JCI Insight上的研究论文中，来自瑞典卡罗琳学院的研究人员通过研究发现证据表明，细菌生物被膜的形成或许是甲型链球菌引发坏死性软组织感染的复杂特性，而生物被膜就是吸附在组织表面上

甲型链球菌可以引发危及生命的坏死性筋膜炎，随后其会快速扩散并且破坏机体的软组织，通常治疗甲型链球菌引发的坏死性软组织感染的疗法需要强化治疗，同时进行手术干预；该疾病通常会导致受影响的肢体被截肢。

近日一项刊登于国际杂志JCI Insight上的研究论文中，来自瑞典卡罗琳学院的研究人员通过研究发现证据表明，细菌生物被膜的形成或许是甲型链球菌引发坏死性软组织感染的复杂特性，而生物被膜就是吸附在组织表面上的一大堆细菌聚集体。

文章中，研究者Anna Norrby-Teglund表示，我们发现了一名甲型链球菌引发坏死性软组织感染的患者似乎对抗生素和手术清除伤口的疗法会产生反应，尽管目前并没有甲型链球菌引发相关的疾病症状，但对患者伤口的再次检查或许就可以发现细菌所形成的较厚的生物被膜。随后在三分之一的研究中，研究者这对坏死性软组织感染的患者进行分析都发现了患者机体伤口处生物被膜的存在。

研究者指出，生物被膜和高度的细菌载量、密集型的炎症发生直接相关，而且相比没有生物被膜的伤口组织样本而言，生物被膜的存在往往会导致伤口出现炎症的组织损伤，本文研究结果就表明，生物被膜或许应当被认为是引发链球菌坏死性软组织感染的复杂因子。

生物被膜的形成往往会改善病原体对抗生素的耐受性和反应性，研究者表示，后期他们还将通过更为深入的研究来评估在感染位点中清除甲型链球菌生物被膜的过程或方法对于减缓感染进展的作用。

原始出处

Nikolai Siemens,1 Bhavya Chakrakodi,1 Srikanth Mairpady Shambat,1 Marina Morgan,2 Helena Bergsten,1 Ole Hyldegaard,3 Steinar Skrede,4 Per Arnell,5 Martin B. Madsen,6 Linda Johansson,1 INFECT Study Group,7 Julius Juarez,1 Lidija Bosnjak,1 Matthias Mörgelin,8 Mattias Svensson,1 and Anna Norrby-Teglund1.Biofilm in group A streptococcal necrotizing soft tissue infections.JCI Insight.2016

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1982029, encodeId=a8da198202904, content=<a href='/topic/show?id=12c010266f0' target=_blank style='color:#2F92EE;'>#JCI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10266, encryptionId=12c010266f0, topicName=JCI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e30378, createdName=caobinglei8079, createdTime=Sun Aug 14 23:36:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362806, encodeId=c8dc1362806cc, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Wed Jul 13 01:36:00 CST 2016, time=2016-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420373, encodeId=423414203e3a3, content=<a href='/topic/show?id=2221935219e' target=_blank style='color:#2F92EE;'>#软组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93521, encryptionId=2221935219e, topicName=软组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=52913579937, createdName=qilu_qi, createdTime=Wed Jul 13 01:36:00 CST 2016, time=2016-07-13, status=1, ipAttribution=)]
    2016-08-14 caobinglei8079

    #JCI#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1982029, encodeId=a8da198202904, content=<a href='/topic/show?id=12c010266f0' target=_blank style='color:#2F92EE;'>#JCI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10266, encryptionId=12c010266f0, topicName=JCI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e30378, createdName=caobinglei8079, createdTime=Sun Aug 14 23:36:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362806, encodeId=c8dc1362806cc, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Wed Jul 13 01:36:00 CST 2016, time=2016-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420373, encodeId=423414203e3a3, content=<a href='/topic/show?id=2221935219e' target=_blank style='color:#2F92EE;'>#软组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93521, encryptionId=2221935219e, topicName=软组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=52913579937, createdName=qilu_qi, createdTime=Wed Jul 13 01:36:00 CST 2016, time=2016-07-13, status=1, ipAttribution=)]
    2016-07-13 millore

    #坏死#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1982029, encodeId=a8da198202904, content=<a href='/topic/show?id=12c010266f0' target=_blank style='color:#2F92EE;'>#JCI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10266, encryptionId=12c010266f0, topicName=JCI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e30378, createdName=caobinglei8079, createdTime=Sun Aug 14 23:36:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362806, encodeId=c8dc1362806cc, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Wed Jul 13 01:36:00 CST 2016, time=2016-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420373, encodeId=423414203e3a3, content=<a href='/topic/show?id=2221935219e' target=_blank style='color:#2F92EE;'>#软组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93521, encryptionId=2221935219e, topicName=软组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=52913579937, createdName=qilu_qi, createdTime=Wed Jul 13 01:36:00 CST 2016, time=2016-07-13, status=1, ipAttribution=)]
    2016-07-13 qilu_qi

    #软组织#

    0