Arthritis Rheumatol：HLA-B27对脊柱关节炎肠道微生态的影响提示了生态失调的环境模式

2017-12-30 xiangting MedSci原创

HLA-B27对SpA肠道微生态和生态失调的影响高度依赖于宿主的遗传背景和/或环境。

这篇文章研究了HLA-B27介导的实验性脊柱关节炎（SpA）是否与一种常见的肠道微生物特征相关联，以识别发病的潜在驱动因素。

使用野生型同窝动物和HLA-B7转基因Lewis大鼠作为对照，比较HLA-B27对3种遗传背景：深色刺鼠（DA）、Lewis和Fischer大鼠的影响。在2,3-4和6-8个月大时，通过组织学分析盲肠和结肠组织或内容物的炎症、RNA-Seq基因表达差异和微生态差异的16S rRNA基因序列。

HLA-B27转基因Lewis和Fischer大鼠出现肠道炎症，DA大鼠对HLA-B27有抗性，而HLA-B7转基因大鼠不受影响。在受影响的Lewis和Fischer大鼠中的免疫失调相似，并由结盲肠IL-23/IL-17、IFN、TNF和IL-1细胞因子和通路的激活主导，而DA大鼠细胞因子失调水平低并没有炎症。HLA-B27转基因大鼠的肠道微生物变化在3种不同的背景上显著不同，包括生态失调模式不同，HLA-B27转基因Lewis和Fischer菌株中有重叠。有趣的是，DA大鼠缺乏促进CD4 + Th17 T细胞发育的分节丝状细菌（SFB），这可以解释它们对疾病的抗性。

HLA-B27对SpA肠道微生态和生态失调的影响高度依赖于宿主的遗传背景和/或环境，尽管同时有免疫通路失调。这些结果提示了一个生态失调的环境模式，其中多种微生物导致异常免疫反应，而不是一个或少数的微生物驱动发病机制。

原始出处：

Tejpal Gill, et al. Effects of HLA-B27 on Gut Microbiota in Experimental Spondyloarthritis Implicate an Ecological Model of Dysbiosis. Arthritis Rheumatol. 29 December 2017.

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2018-05-28 ms3153534357578991

#HLA-B#

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2018-08-31 12498dd9m11暂无昵称

#HLA-B27#

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2018-03-26 ms6390871039024434

#Arthritis#

23 0
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2018-01-01 lmm397

#关节炎#

27 0
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2018-01-01 fengting3

#脊柱关节炎#

36 0
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2018-01-01 zhaojie88

#ART#

25 0
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2018-01-01 marongnuan

#HLA#

24 0
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2017-12-30 明崖

学习了.值得探讨深入研究

54 0
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2017-12-30 天涯183

非常好的文章.学习了

62 0

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Arthritis Rheumatol：HLA-B27对脊柱关节炎肠道微生态的影响提示了生态失调的环境模式

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