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Unum Therapeutics宣布研究性新药（IND）申请：抗体偶联T细胞受体（ACTR）细胞疗法和曲妥珠单抗联合治疗HER2阳性晚期癌症

2018-08-14 MedSci MedSci原创

抗体偶联T细胞受体细胞治疗曲妥珠单抗HER2
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Unum的新型专利技术抗体偶联T细胞受体（antibody-coupled T cell receptor， ACTR）是一种通用的工程细胞疗法。

Unum Therapeutics Inc.（纳斯达克股票代码：UMRX）是一家临床阶段的生物制药公司，致力于新型免疫治疗产品的开发和商业化，利用患者免疫系统的力量来治愈癌症。Unum的新型专利技术抗体偶联T细胞受体（antibody-coupled T cell receptor， ACTR）是一种通用的工程细胞疗法。该公司于2018年8月13日宣布一项研究性新药（IND）申请，通过联合使用ACTR的 T细胞疗法与曲妥珠单抗，治疗HER2+晚期癌症患者。这是Unum公司的ACTR技术第一次被用于治疗实体肿瘤，也是公司的第四个临床试验计划。

抗体偶联T细胞受体（ACTR）技术是利用抗体对肿瘤细胞的靶向，使得ACTR T细胞发挥对肿瘤细胞的杀伤作用。ACTR T细胞本身不能识别肿瘤细胞，但是其胞外区是FcR (CD16)能够与抗体Fc结构域结合。靶向肿瘤的抗体结合肿瘤细胞表面，从而使ACTR T细胞识别肿瘤细胞。这样一来，ACTR T细胞就能够发挥抗体依赖性细胞毒性(ADCC)杀死肿瘤细胞。

作为细胞疗法，ACTR具有内在的优势，因为其活性受抗体剂量控制。可以通过增加或减少靶向抗体的量来限定细胞毒杀伤和副作用之间的治疗窗口。

Unum首席执行官查克威尔逊表示："ACTR代表了一种可以用于靶向不同肿瘤类型的创新技术，具有远大的前景。能够将该技术扩展到靶向实体肿瘤是令人兴奋的。我们将努力为需要更好治疗选择的HER2 +晚期癌症患者开发ACTR细胞疗法。"

Unum准备在2018年底之前在患有HER2 +晚期癌症的患者中启动一项名为ATTCK-34-01的多中心I期试验。ATTCK-34-01被设计为剂量递增研究，其中ACTR T细胞药物产品和曲妥珠单抗剂量均升级，以确定组合的安全性、耐受性和抗肿瘤活性。

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    2019-02-12 124988c7m106暂无昵称

    #ERA#

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    2018-10-03 feather89

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    2018-08-26 ms24272190615788285182

    #Therapeutic#

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    2018-08-29 仁心济世

    #曲妥珠#

    0

  5. 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    2018-08-16 闆锋旦

    #HER2阳性#

    0

  6. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313711, encodeId=8eb81313e110f, content=<a href='/topic/show?id=d4cc80e128f' target=_blank style='color:#2F92EE;'>#联合治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80712, encryptionId=d4cc80e128f, topicName=联合治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=263b421, createdName=zhaozuguo, createdTime=Thu Aug 16 02:15:00 CST 2018, time=2018-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350812, encodeId=d6371350812e9, content=<a href='/topic/show?id=a2fb1e385a1' target=_blank style='color:#2F92EE;'>#therapeutics#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17385, encryptionId=a2fb1e385a1, topicName=therapeutics)], attachment=null, authenticateStatus=null, 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    2018-08-16 zhaozuguo

    #联合治疗#

    0

  7. 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    2018-08-16 仁心济世

    #therapeutics#

    0

  8. 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    2018-08-16 xiaogang319

    #IND#

    0

  9. 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    2018-08-16 12498e67m32暂无昵称

    #T细胞受体#

    0