JCEM:糖尿病患者心血管住院和再住院风险评分!

2018-01-09 xing.T MedSci原创

由此可见,该研究已经开发并通过外部验证了两个新的预测心血管疾病住院和再住院风险的预测模型。它们是基于在许多发达国家初级保健机构中为2型糖尿病患者提供的少量临床测量结果,并且其可以作为筛查心血管疾病住院和再住院高风险人群的工具。

血管疾病(CVD)是2型糖尿病患者住院和再住院的常见和昂贵原因。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在开发和外部验证心血管住院和心血管再住院的两种风险预测模型。

该研究包含了两个独立的前瞻性队列,衍生队列包括来自剑桥的18个社区全科诊所的4704例2型糖尿病患者。验证队列包括来自1121名2型糖尿病患者试验后的随访数据。该研究的主要研究结局指标为心血管病住院2年以上,既往心血管病住院后90天以后因心血管疾病的再住院情况。

研究人员发现衍生队列心血管住院和再住院的绝对率分别为12.5%和6.7%,验证队列分别为16.3%和7.0%。模型的判别能力在两个队列中表现相似,C统计值在0.70以上,对观察到的和预测的风险进行了很好的校准。

由此可见,该研究已经开发并通过外部验证了两个新的预测心血管疾病住院和再住院风险的预测模型。它们是基于在许多发达国家初级保健机构中为2型糖尿病患者提供的少量临床测量结果,并且其可以作为筛查心血管疾病住院和再住院高风险人群的工具。

原始出处:

Dahai Yu,et al. Development and external validation of risk scores for cardiovascular hospitalisation and rehospitalisation in diabetes patients.J Clin Endocrinol Metab. 2017. https://doi.org/10.1210/jc.2017-02293

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1777737, encodeId=cabc1e777375a, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Mon Mar 05 00:50:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063119, encodeId=fbd22063119da, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Wed Sep 05 03:50:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251710, encodeId=7ca51251e109d, content=<a href='/topic/show?id=fab72646628' target=_blank style='color:#2F92EE;'>#住院风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26466, encryptionId=fab72646628, topicName=住院风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93e223, createdName=bluefate121, createdTime=Thu Jan 11 03:50:00 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474401, encodeId=a37014e44016b, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Thu Jan 11 03:50:00 CST 2018, time=2018-01-11, status=1, ipAttribution=)]
    2018-03-05 smallant2015
  2. [GetPortalCommentsPageByObjectIdResponse(id=1777737, encodeId=cabc1e777375a, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Mon Mar 05 00:50:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063119, encodeId=fbd22063119da, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Wed Sep 05 03:50:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251710, encodeId=7ca51251e109d, content=<a href='/topic/show?id=fab72646628' target=_blank style='color:#2F92EE;'>#住院风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26466, encryptionId=fab72646628, topicName=住院风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93e223, createdName=bluefate121, createdTime=Thu Jan 11 03:50:00 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474401, encodeId=a37014e44016b, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Thu Jan 11 03:50:00 CST 2018, time=2018-01-11, status=1, ipAttribution=)]
    2018-09-05 achengzhao
  3. [GetPortalCommentsPageByObjectIdResponse(id=1777737, encodeId=cabc1e777375a, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Mon Mar 05 00:50:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063119, encodeId=fbd22063119da, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Wed Sep 05 03:50:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251710, encodeId=7ca51251e109d, content=<a href='/topic/show?id=fab72646628' target=_blank style='color:#2F92EE;'>#住院风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26466, encryptionId=fab72646628, topicName=住院风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93e223, createdName=bluefate121, createdTime=Thu Jan 11 03:50:00 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474401, encodeId=a37014e44016b, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Thu Jan 11 03:50:00 CST 2018, time=2018-01-11, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1777737, encodeId=cabc1e777375a, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Mon Mar 05 00:50:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063119, encodeId=fbd22063119da, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Wed Sep 05 03:50:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251710, encodeId=7ca51251e109d, content=<a href='/topic/show?id=fab72646628' target=_blank style='color:#2F92EE;'>#住院风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26466, encryptionId=fab72646628, topicName=住院风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93e223, createdName=bluefate121, createdTime=Thu Jan 11 03:50:00 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474401, encodeId=a37014e44016b, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Thu Jan 11 03:50:00 CST 2018, time=2018-01-11, status=1, ipAttribution=)]

相关资讯

Diatetes:Cinaciguat,cGMP激活剂,有望用于治疗糖尿病相关的骨质疏松。

骨质丢失和骨折是I型糖尿病未公认的并发症,主要是由于成骨细胞的骨形成受损导致。在糖尿病中导致成骨细胞功能障碍的机制尚未完全明确,但胰岛素缺乏、血糖控制不良和高血糖诱导的氧化应激,可能都有一定作用。在本研究中,Kema Kalyanaraman等人发现胰岛素可通过一氧化氮(NO)/cGMP/蛋白激酶G(PKG)信号转导通路促进成骨细胞增殖和存活,而且Akt的PKG刺激具有正反馈作用。成骨细胞暴露在高

J Prim Care Commun Heal:双治疗优于二甲双胍,更适合低收入2型糖尿病患者

根据《初级保健和社区保健》最近发表的研究报告,双治疗优于二甲双胍单药治疗或过渡疗法,对于新诊断的2型糖尿病的低收入个体可能是首选的。

Circ Res:研究揭示脂肪是如何破坏心脏健康的!

爱荷华大学的一项研究已经确定了心脏中多余的脂肪是糖尿病和肥胖症的共同特征,如何损害细胞产生能量的基本能力。研究人员认为,该机制可能导致糖尿病患者心脏衰竭风险增加2至5倍。

Am J Cardiol:研究显示,PCI增加了依赖胰岛素的糖尿病患者心梗死风险

糖尿病是一种威胁全球健康的慢性疾病,随着病情的发展,大部分糖尿病患者都由最初的药物控制转变为胰岛素控制。胰岛素逐渐成为了糖尿病患者离不开的存在。

BMJ:吃糖致肥胖和糖尿病有更深层次原因?

近些年对糖的质疑此起彼伏,近日BMJ上发表的一篇文章又对糖发起了攻击。

Plos One:糖尿病会将预期寿命减少5年到7年

研究结果表明,与没有糖尿病的老年人相比,患有糖尿病的老年人认知功能障碍的几率更高,寿命也更短。