礼来携手勃林格殷格翰研发乳腺癌组合疗法

2016-07-20 佚名不详

制药巨头礼来和勃林格殷格翰近日达成一项研究合作，二者将共同研发乳腺癌联合用药。此次合作的焦点是研究勃林格殷格翰胰岛素样生长因子-1/2（IGF-1/2)配体的中和抗体BI 836845和礼来CDK4/CDK6抑制剂abemaciclib联合疗法在乳腺癌中的安全性和有效性。 Ib期安全性试验将于今年开展，受试者为确诊HR+/HER2-的晚期乳腺癌患者。如果进展顺利，双方继续开展中期临床试验，以及在

制药巨头礼来和勃林格殷格翰近日达成一项研究合作，二者将共同研发乳腺癌联合用药。此次合作的焦点是研究勃林格殷格翰胰岛素样生长因子-1/2（IGF-1/2)配体的中和抗体BI 836845和礼来CDK4/CDK6抑制剂abemaciclib联合疗法在乳腺癌中的安全性和有效性。

Ib期安全性试验将于今年开展，受试者为确诊HR+/HER2-的晚期乳腺癌患者。如果进展顺利，双方继续开展中期临床试验，以及在其它实体瘤中进行临床试验。

勃林格殷格翰实体瘤治疗部门负责人Mehdi Shahidi博士表示，非常高兴能够和礼来展开这次合作，希望联合用药能对转移性乳腺癌患者产生良好的疗效。勃林格的BI 836845已被证实能够抑制肿瘤生长，并且在和诺华Afinitor (everolimus)、辉瑞Aromasin (exemestane)联用的早期临床试验中，已经表现出安全性和有效性。而礼来的abemaciclib作为CDK4和CDK6抑制剂，能够有效抑制肿瘤增殖。勃林格和礼来认为，将这两种药物联用，能够对细胞增殖的信号通路产生更加全面的干扰，进而延长细胞周期阻滞的周期，达到更好的治疗效果。并且这两种药物联用还有可能逆转激素治疗抵抗的现象。

勃林格的肿瘤部门在2013年收获了第一个批文，其肺癌药物Gilotrif (afatinib)获得了FDA的批准。目前勃林格正在努力发展其肿瘤业务。相比而言礼来的肿瘤管线发展更为成熟，其畅销药物Alimta (pemetrexed)、Erbitux (cetuximab)和Gemzar (gemcitabine)都是肿瘤管线的重磅产品。遗憾的是，礼来没有及时赶上免疫治疗这一浪潮，尽管公司和默沙东达成合作协议，但在PD-1/PD-L1抑制剂方面没有拿得出手的候选药物。礼来的abemaciclib已经在乳腺癌中获得了FDA授予的“突破性疗法”认定，有望在不久的将来获批。并且该药物也在许多实体瘤中展开临床试验。

原始出处：

Lilly and Boehringer team up for experimental breast cancer trial pact

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2017-09-04 1e145228m78(暂无匿称)

学习了谢谢作者分享!

67 0
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2017-03-12 yankaienglish

#组合疗法#

40 0
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2016-09-19 ylzr123

好文，从这里学习了好多新知识，新信息。赞了！

60 0
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2016-07-22 lqvr

#研发#

25 0
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2016-07-22 ymljack

#勃林格殷格翰#

29 0

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