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Stem cells：血管内皮祖细胞亚群的全新标志物

2017-01-25 MedSci MedSci原创

血管内皮祖细胞标志物
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至今为止，血管相关内皮细胞祖细胞仍然研究不足，在胚胎或出生后阶段，它们在新形成脉管系统中的作用仍然难以捉摸。近期，一项发表在Stem cells杂志上的文章率先定义了一组在胚胎发育期间高度表达的基因，并在成年小鼠中急剧下调。随后，研究者们集中研究了祖细胞标记物Peg3/PW1。通过脉管系统的体内染色，研究者们发现只有一部分细胞共表达内皮标志物和PW1。这些细胞在胚胎血管系统中相当丰富，但在出生后和

至今为止，血管相关内皮细胞祖细胞仍然研究不足，在胚胎或出生后阶段，它们在新形成脉管系统中的作用仍然难以捉摸。


近期，一项发表在Stem cells杂志上的文章率先定义了一组在胚胎发育期间高度表达的基因，并在成年小鼠中急剧下调。

随后，研究者们集中研究了祖细胞标记物Peg3/PW1。

通过脉管系统的体内染色，研究者们发现只有一部分细胞共表达内皮标志物和PW1。这些细胞在胚胎血管系统中相当丰富，但在出生后和成熟阶段的数量减少。

使用PW1表达小鼠，研究者们已经能够分离PW1阳性和阴性内皮细胞。PW1阳性细胞与PW1阴性细胞相比是高度增殖的，并且以克隆稀释接种时能够形成集落。

此外，通过RNAseq分析，PW1阳性细胞表达内皮细胞标记及间充质干细胞和干细胞的标记。

当在体外由内皮生长因子攻击时，PW1阳性细胞能够比PW1阴性细胞增殖更多，并可以在体内有效形成新的血管。

总之，这些研究数据鉴定了具有祖细胞特征的血管相关内皮细胞的亚组。考虑到它们高度增殖的潜力，这些细胞对于设计治疗改善缺血组织的灌注或促进血管修复可能特别重要。

原始出处：
Malinverno M, Corada M, Ferrarini L, et al. Peg3/PW1 is a marker of a subset of vessel associated endothelial progenitors. Stem Cells. 2017 Jan 16. doi: 10.1002/stem.2566.

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    2017-09-13 hb2008ye

    #stem cell#

    0

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    2017-10-08 yykkxiaodou

    #stem cells#

    0

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time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614929, encodeId=227e16149295e, content=<a href='/topic/show?id=d74a44e2e7' target=_blank style='color:#2F92EE;'>#cells#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4472, encryptionId=d74a44e2e7, topicName=cells)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=659819575782, createdName=124988c7m101暂无昵称, createdTime=Fri Jan 27 05:42:00 CST 2017, time=2017-01-27, status=1, ipAttribution=)]
    2017-03-02 zhaozhouchifen

    #Cell#

    0

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time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614929, encodeId=227e16149295e, content=<a href='/topic/show?id=d74a44e2e7' target=_blank style='color:#2F92EE;'>#cells#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4472, encryptionId=d74a44e2e7, topicName=cells)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=659819575782, createdName=124988c7m101暂无昵称, createdTime=Fri Jan 27 05:42:00 CST 2017, time=2017-01-27, status=1, ipAttribution=)]
    2017-03-28 hukaixun

    #标志物#

    0

  5. 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time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614929, encodeId=227e16149295e, content=<a href='/topic/show?id=d74a44e2e7' target=_blank style='color:#2F92EE;'>#cells#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4472, encryptionId=d74a44e2e7, topicName=cells)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=659819575782, createdName=124988c7m101暂无昵称, createdTime=Fri Jan 27 05:42:00 CST 2017, time=2017-01-27, status=1, ipAttribution=)]
    2017-12-07 维他命

    #CEL#

    0

  6. 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time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614929, encodeId=227e16149295e, content=<a href='/topic/show?id=d74a44e2e7' target=_blank style='color:#2F92EE;'>#cells#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4472, encryptionId=d74a44e2e7, topicName=cells)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=659819575782, createdName=124988c7m101暂无昵称, createdTime=Fri Jan 27 05:42:00 CST 2017, time=2017-01-27, status=1, ipAttribution=)]
    2017-01-31 Jackie Li

    收藏

    0

  7. 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href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Fri Jan 27 05:42:00 CST 2017, time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512418, encodeId=146915124182f, content=<a href='/topic/show?id=f802e4102cb' target=_blank style='color:#2F92EE;'>#祖细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74102, encryptionId=f802e4102cb, topicName=祖细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f18310470858, createdName=12498636m52(暂无昵称), createdTime=Fri Jan 27 05:42:00 CST 2017, time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614929, encodeId=227e16149295e, content=<a href='/topic/show?id=d74a44e2e7' target=_blank style='color:#2F92EE;'>#cells#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4472, encryptionId=d74a44e2e7, topicName=cells)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=659819575782, createdName=124988c7m101暂无昵称, createdTime=Fri Jan 27 05:42:00 CST 2017, time=2017-01-27, status=1, ipAttribution=)]
    2017-01-29 Jackie Li

    收藏

    0

  8. 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href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Fri Jan 27 05:42:00 CST 2017, time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512418, encodeId=146915124182f, content=<a href='/topic/show?id=f802e4102cb' target=_blank style='color:#2F92EE;'>#祖细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74102, encryptionId=f802e4102cb, topicName=祖细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f18310470858, createdName=12498636m52(暂无昵称), createdTime=Fri Jan 27 05:42:00 CST 2017, time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614929, encodeId=227e16149295e, content=<a href='/topic/show?id=d74a44e2e7' target=_blank style='color:#2F92EE;'>#cells#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4472, encryptionId=d74a44e2e7, topicName=cells)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=659819575782, createdName=124988c7m101暂无昵称, createdTime=Fri Jan 27 05:42:00 CST 2017, time=2017-01-27, status=1, ipAttribution=)]
    2017-01-27 12498bb3m92(暂无昵称)

    #STEM#

    0

  9. 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time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614929, encodeId=227e16149295e, content=<a href='/topic/show?id=d74a44e2e7' target=_blank style='color:#2F92EE;'>#cells#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4472, encryptionId=d74a44e2e7, topicName=cells)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=659819575782, createdName=124988c7m101暂无昵称, createdTime=Fri Jan 27 05:42:00 CST 2017, time=2017-01-27, status=1, ipAttribution=)]
    2017-01-27 12498636m52(暂无昵称)

    #祖细胞#

    0

  10. 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time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614929, encodeId=227e16149295e, content=<a href='/topic/show?id=d74a44e2e7' target=_blank style='color:#2F92EE;'>#cells#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4472, encryptionId=d74a44e2e7, topicName=cells)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=659819575782, createdName=124988c7m101暂无昵称, createdTime=Fri Jan 27 05:42:00 CST 2017, time=2017-01-27, status=1, ipAttribution=)]
    2017-01-27 124988c7m101暂无昵称

    #cells#

    0

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流行病学研究已经证明支气管哮喘患者的心血管事件发生率增加，但至今为止对哮喘和血管功能之间的关系知之甚少。近期，一项发表在Respir Res杂志上的研究评估了儿童和青少年哮喘患者的血管内皮功能和动脉硬化。此项研究为横断面对照研究。使用反应性充血指数的自然对数（LnRHI）和增加指数（AIx@75％）方法检测非侵入性外周动脉压力（EndoPAT2000），分别测量了哮喘组（13.6±0.6岁）和对照

胆固醇毁坏血管只需四步！常见食物的胆固醇含量，一定要记住！

有研究数据显示，中国居民冠心病死亡率增加，77%是由于血液胆固醇升高所引起！虽然中国、美国今年都陆续取消了胆固醇摄入300克的上限，但是并不意味着可以随便吃！   虽然，食物里的胆固醇不区分“好”或“坏”，但是当胆固醇被脂蛋白“包装”进入血液之后，就出现了“好”或“坏”之分。 胆固醇有好的，也有坏的 1 高密度脂蛋白（HDL） 俗称“好胆固醇”

新研究成果为动脉粥样硬化的治疗找到新靶标

日前，香港中文大学深圳研究院黄聿教授与天津医科大学朱毅教授的研究团队联合攻关，在动脉粥样硬化形成机制方面的研究取得突破性进展，相关研究成果发布于《自然》。 血管内皮细胞是形成血管内壁表面的细胞层，不断受到血液流动机械力的冲刷，不同的剪切力会引发不同的细胞应答，如果出现异常就会引发血管炎症，动脉粥样硬化等疾病。YAP/TAZ是细胞内重要的转录调控因子，长期以来被视为一种癌基因，处于Hippo

Lancet：全球房颤患者诊疗大比拼：中国卒中发生率竟与非洲比肩，原来是这两件事儿未做好

Lancet杂志近期公布了RELY房颤注册研究全球47个国家的急诊房颤注册结果。该研究共登记约1.5例房颤患者，并随访了1年，其中4%的患者发生了卒中。中国房颤患者1年卒中发生率7%，仅次于非洲（8%）。印度最低（1%），北美3%。 中国有服用抗凝药物指证的房颤患者中，有70%未应用抗凝药物。在47个国家中最差。但作者也表示，除抗凝药物应用不足之外，中国和非洲的卒中发生率高，也与高血压控