Stroke:CT灌注可预测急性缺血性卒中的功能结局

2018-09-16 国际循环编辑部 国际循环

近期,Stroke发表的一项最新研究比较了Alberta卒中项目早期CT评分(ASPECTS)自动ASPECTS及CT灌注缺血核心体积对大血管闭塞18小时内的缺血性卒中临床结局的预测价值。

近期,Stroke发表的一项最新研究比较了Alberta卒中项目早期CT评分(ASPECTS)自动ASPECTS及CT灌注缺血核心体积对大血管闭塞18小时内的缺血性卒中临床结局的预测价值。

研究对CRISP研究(计算机断层扫描灌注预测缺血性卒中再通反应)中成功实现再灌注的156例急性缺血性卒中患者进行分析,采用e-ASPECTS软件计算自动ASPECTS,采用RAPID软件评估缺血核心体积。于校正相关临床混杂因素后,行单因素及多因素分析评估上述影像学特征与结局较好(改良Rankin量表评分0~2分)、结局较差(改良Rankin量表评分4~6)的相关性。

单因素分析显示,传统ASPECTS及自动ASPECTS均与结局较好或较差无相关性(所有P值均无显著性)。多因素分析显示,自动ASPECTS与结局较好具有相关性(P=0.02),与结局较差并无相关性。单因素及多因素分析中,缺血核心体积均与结局较好及较差具有相关性(单因素分析P值分别<0.01和=0.04;多因素分析P值分别为0.03和0.02)。受试者工作特征分析显示,计算机断层扫描灌注预测患者结局良好的曲线下面积为0.62(95%CI:0.53~0.71),最佳核心体积界值为15 ml。

综上可见,在发病18小时内实现血管内再灌注的急性缺血性卒中患者中,CT灌注所示的缺血核心体积是临床结局的预测因素;而传统或自动ASPECTS对其结局并无预测价值。

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    2018-09-16 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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    2018-09-16 天地飞扬

    了解一下,谢谢分享!

    0

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