J Oral Implantol:种植体周围炎治疗时的局部给药特性

2018-12-10 MedSci MedSci原创

局部递送剂广泛用于种植体周围炎治疗,本研究旨在确定残留在牙种植体表面上的局部递送剂,并在应用各种清洁方法后分析这些残留物的组分。使用喷砂,大砂砾,酸蚀处理植体表面。在植体表面上施用四种局部递送剂:氯己定凝胶(组2),四环素溶液(组3)和两种米诺环素盐酸盐试剂(组4和5)。第1组包含生理盐水作为对照。两种清洗方法应用于不同的持续时间:(1)运行蒸馏水10秒(亚组A),5分钟(亚组B)和15分钟(亚组

局部递送剂广泛用于种植体周围炎治疗,本研究旨在确定残留在牙种植体表面上的局部递送剂,并在应用各种清洁方法后分析这些残留物的组分。

使用喷砂,大砂砾,酸蚀处理植体表面。在植体表面上施用四种局部递送剂:氯己定凝胶(组2),四环素溶液(组3)和两种米诺环素盐酸盐试剂(组4和5)。第1组包含生理盐水作为对照。两种清洗方法应用于不同的持续时间:(1)运行蒸馏水10秒(亚组A),5分钟(亚组B)和15分钟(亚组C); (2)牙科椅的喷水10秒(D组)和5分钟(E组)。扫描电子显微镜和能量色散X射线光谱用于分析植体的表面形态和残留组分。

结果显示,从组1,2,3和5中的植入物表面移除的局部递送剂的量随着清洁持续时间和压力而增加。然而,在所有清洁条件下,Minocline仍保留在第4组的植体表面上。由于其疏水性,Minocline无法用水清洗干净。因此,应仔细考虑在种植体表面直接使用这种药物进行种植体周围炎的治疗。

在植体表面上没有药物功效的局部递送剂残留物的存在可能干扰骨再整合并充当微生物的储库。

原始出处:

Lee JB, Kweon HH, et al., Characteristics of Local Delivery Agents for Treating Peri-implantitis on Dental Implant Surfaces: A Preclinical Study. J Oral Implantol. 2018 Nov 19. doi: 10.1563/aaid-joi-D-17-00261.

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    2019-02-22 xuyong536
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    2019-05-21 xuyu
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    2019-07-20 huangdf
  4. [GetPortalCommentsPageByObjectIdResponse(id=1773245, encodeId=07a31e732451a, content=<a href='/topic/show?id=5298121e46e' target=_blank style='color:#2F92EE;'>#MPL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12174, encryptionId=5298121e46e, topicName=MPL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10e638510530, createdName=xuyong536, createdTime=Fri Feb 22 03:16:00 CST 2019, time=2019-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789224, encodeId=78d31e892242e, content=<a href='/topic/show?id=0c8814344f5' target=_blank style='color:#2F92EE;'>#plant#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14344, encryptionId=0c8814344f5, topicName=plant)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Tue May 21 18:16:00 CST 2019, time=2019-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702023, encodeId=78491e02023bf, content=<a href='/topic/show?id=04b9e4784aa' target=_blank style='color:#2F92EE;'>#种植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74784, encryptionId=04b9e4784aa, topicName=种植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47e130405619, createdName=huangdf, createdTime=Sat Jul 20 20:16:00 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020524, encodeId=7785202052482, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Sat Apr 27 09:16:00 CST 2019, time=2019-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343856, encodeId=3743134385695, content=<a href='/topic/show?id=d512e47853f' target=_blank style='color:#2F92EE;'>#种植体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74785, encryptionId=d512e47853f, topicName=种植体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TnzXXl41yf6V8fHrDb5JdtxOgpaY6vplUhHtL8BzDh1xMtcap9H1IOlE8umxPGovhIuVkeGTY26eNUFCFaOheQ/132, createdBy=29702500197, createdName=ms6279672939590805, createdTime=Tue Dec 11 17:16:00 CST 2018, time=2018-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405878, encodeId=b89114058e8f9, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Tue Dec 11 17:16:00 CST 2018, time=2018-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354980, encodeId=3dc535498008, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Dec 10 08:31:10 CST 2018, time=2018-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354979, encodeId=07203549e9bd, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Mon Dec 10 08:30:19 CST 2018, time=2018-12-10, status=1, ipAttribution=)]
    2019-04-27 小几洁
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    2018-12-11 chg122
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    2018-12-10 龙胆草

    学习谢谢分享

    0

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