Mol Med Rep:龈下菌群失调可促进牙周炎的发生

2017-06-18 MedSci MedSci原创

牙周炎是口腔最常见的炎症性疾病之一,导致结缔组织退缩和牙齿逐渐脱落。牙周炎的其中一个表现是牙周袋的形成,袋内厌氧菌和革兰氏阴性菌可迅速增殖。因此,龈下菌群的改变被认为是牙周炎发生的主要病因。 既往研究发现,吸烟者牙周病的患病率和严重性都有增加,这表明吸烟是导致牙周炎发生发展的一个危险因素。 本研究采用16S rRNA序列分析法评估6名吸烟慢性牙周炎患者、6名非吸烟慢性牙周炎患者和8

牙周炎是口腔最常见的炎症性疾病之一,导致结缔组织退缩和牙齿逐渐脱落。牙周炎的其中一个表现是牙周袋的形成,袋内厌氧菌和革兰氏阴性菌可迅速增殖。因此,龈下菌群的改变被认为是牙周炎发生的主要病因。


既往研究发现,吸烟者牙周病的患病率和严重性都有增加,这表明吸烟是导致牙周炎发生发展的一个危险因素。

本研究采用16S rRNA序列分析法评估6名吸烟慢性牙周炎患者、6名非吸烟慢性牙周炎患者和8名健康对照者的龈下菌群。

结果显示,牙周炎患者的微生物结构发生了明显变化。吸烟者和非吸烟者的牙周炎患者,牙周炎龈下菌群Parvimonans、Desulfubulbus、Paludibacter,Haemophilus和 Sphaerochaeta属具有相对较高的丰都。

由于对16S rRNA测序法具有很高的精确度和灵敏度,低丰度属(包括Pedobacter、Granulicatella、Paracoccus、Atopobium、Bifidobacterium、Coprococcus、Oridobacteriu、Peptococcus、Oscillospira 和 Akkermansia)也出现了检测结果,并显示新的菌型与牙周炎的发生相关。

值得注意的是,吸烟患者主要微生物群落的变化更明显,提示吸烟与龈下菌群失调的严重程度相关。总而言之,目前的研究证实,慢性牙周炎是一个多种致病菌引起的疾病,龈下菌群失调可促进疾病的加重。

原始出处:

Lorena Coretti,Mariella Cuomo, et al., Subgingival dysbiosis in smoker and non-smoker patients with chronic periodontitis. Mol Med Rep. 2017 Apr; 15(4): 2007–2014. Published online 2017 Mar 1. doi:  10.3892/mmr.2017.6269.

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    2017-06-18 明心见性

    学习了,谢谢分享

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1450531, encodeId=c5db14505312e, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue Jun 20 04:01:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607666, encodeId=3089160e6661b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Jun 20 04:01:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212388, encodeId=6877212388e7, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplCaQGBmjHytXQqvsuocO2uV2lOAaJibzDafJudKToVfU12LzwArHDb4TSrmU2hk5Qxzc6icoicBK3Dg/0, createdBy=a7901968505, createdName=明心见性, createdTime=Sun Jun 18 17:14:16 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212378, encodeId=98962123e86a, content=了解了解一下了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sun Jun 18 16:27:42 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212352, encodeId=94302123523e, content=口腔微生物的变化可能与很多口腔疾病有关系。实际上全身系统性疾病也可能会引发口腔的改变,在中医中上火,舌苔变化呀这些都有可能是口腔微生物改变的结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 18 14:34:56 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212342, encodeId=b1b821234205, content=注意加强口腔卫生和保健, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sun Jun 18 14:04:07 CST 2017, time=2017-06-18, status=1, ipAttribution=)]
    2017-06-18 xiaotaiyang1

    了解了解一下了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1450531, encodeId=c5db14505312e, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue Jun 20 04:01:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607666, encodeId=3089160e6661b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Jun 20 04:01:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212388, encodeId=6877212388e7, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplCaQGBmjHytXQqvsuocO2uV2lOAaJibzDafJudKToVfU12LzwArHDb4TSrmU2hk5Qxzc6icoicBK3Dg/0, createdBy=a7901968505, createdName=明心见性, createdTime=Sun Jun 18 17:14:16 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212378, encodeId=98962123e86a, content=了解了解一下了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sun Jun 18 16:27:42 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212352, encodeId=94302123523e, content=口腔微生物的变化可能与很多口腔疾病有关系。实际上全身系统性疾病也可能会引发口腔的改变,在中医中上火,舌苔变化呀这些都有可能是口腔微生物改变的结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 18 14:34:56 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212342, encodeId=b1b821234205, content=注意加强口腔卫生和保健, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sun Jun 18 14:04:07 CST 2017, time=2017-06-18, status=1, ipAttribution=)]
    2017-06-18 lovetcm

    口腔微生物的变化可能与很多口腔疾病有关系。实际上全身系统性疾病也可能会引发口腔的改变,在中医中上火,舌苔变化呀这些都有可能是口腔微生物改变的结果

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1450531, encodeId=c5db14505312e, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue Jun 20 04:01:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607666, encodeId=3089160e6661b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Jun 20 04:01:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212388, encodeId=6877212388e7, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplCaQGBmjHytXQqvsuocO2uV2lOAaJibzDafJudKToVfU12LzwArHDb4TSrmU2hk5Qxzc6icoicBK3Dg/0, createdBy=a7901968505, createdName=明心见性, createdTime=Sun Jun 18 17:14:16 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212378, encodeId=98962123e86a, content=了解了解一下了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sun Jun 18 16:27:42 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212352, encodeId=94302123523e, content=口腔微生物的变化可能与很多口腔疾病有关系。实际上全身系统性疾病也可能会引发口腔的改变,在中医中上火,舌苔变化呀这些都有可能是口腔微生物改变的结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 18 14:34:56 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212342, encodeId=b1b821234205, content=注意加强口腔卫生和保健, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sun Jun 18 14:04:07 CST 2017, time=2017-06-18, status=1, ipAttribution=)]
    2017-06-18 楠博One

    注意加强口腔卫生和保健

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