Cancer Epidemiology:绝经女性乳腺癌发病率增高与其是否患有牙周疾病有关

2015-12-21 chenshuo译 MedSci原创

http://www.medicalnewstoday.com/articles/304323.php

近日,据癌症流行病学杂志上最新发表的一项研究结果表明,患有牙周疾病的绝经女性更易患乳腺癌。其中,有吸烟史的女性发病率可能更高。


牙周病是日常生活中是一种很常见的疾病,若不加以治疗,通常会由单纯的牙龈发炎演变为对牙周软组织及其周围牙骨质等的严重损害。

在以往的研究中,人们已经发现牙周病与心脏病、中风、糖尿病以及口腔、食道、头颈、胰腺癌和肺癌的发病有着紧密的联系。而牙周病的慢性炎症是最主要的影响因素。

为了探讨牙周病是否与乳腺癌的发病存在一定的关联,纽约布法罗大学流行病学和环境卫生学系特聘教授Jo L. Freudenheim带领着他的团队进行了一系列的调查研究。

该研究团队对73737名参加过妇女健康倡议观察研究的绝经妇女进行跟踪随访调查。在这些女性当中,没有人曾经有患过乳腺癌的,但其中有26.1%的人患有牙周病。

由于在以往的研究中已经表明,吸烟会影响牙周病的发展,因此该研究小组成员将吸烟也作为影响因素也考虑在内。

研究结果发现,在平均6.7年的随访时间中,共有2124名女性被诊断为乳腺癌。此外,研究人员还发现,在所有的女性当中,有牙周病的女性患乳腺癌的几率是14%。在过去20年内戒烟的女性中,患牙周病的女性患乳腺癌的风险高出36%。

另外,该研究结果的数据表明,在研究期间吸烟的女性患乳腺癌的几率为32%,而如果他们同时患有牙周病,则该数据没有统计学意义。

而对于那些从不吸烟的女性患乳腺癌的几率增加了6%,20年前戒烟的患有牙周病的女性患乳腺癌的几率增加了8%。

最后,Jo L. Freudenheim解释道:

“我们都知道,那些从未吸烟和以往吸烟而目前已经戒烟的人的口腔内细菌菌落是不一样的。而这为乳腺癌和牙周病的之间的关系唯一可能的解释是两者不同的菌落进入到人体的血液循环,并最终影响乳腺组织的发展。”

然而,这仍需进一步的研究来证实。

事实上,对于该研究还存在一定的限制性,如当问及这些女性自我报告牙周疾病状态时,他们说曾经有牙医告诉她们自己牙齿的状况。

同时,这些女性曾经参与过国家健康研究,因此,他们更有可能比一般人群接受定期的医疗和牙科保健,他们的健康意识可能也比一般人群高出不少。

原始出处:

Not just a toothache: periodontal disease linked to breast cancer MNT 21 Dec 2015

Periodontal disease and breast cancer: prospective cohort study of postmenopausal women, Jo L. Freudenheim et al., Cancer Epidemiology, Biomarkers & Prevention 21 December 2015

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    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

    0

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  4. 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  5. 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  6. 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href='/topic/show?id=cdfce8879b1' target=_blank style='color:#2F92EE;'>#绝经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78879, encryptionId=cdfce8879b1, topicName=绝经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Wed Dec 23 08:19:00 CST 2015, time=2015-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450442, encodeId=1d341450442b0, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Wed Dec 23 08:19:00 CST 2015, time=2015-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484071, encodeId=252914840e173, content=<a href='/topic/show?id=1a296e52078' target=_blank style='color:#2F92EE;'>#牙周疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67520, encryptionId=1a296e52078, topicName=牙周疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0c97946807, createdName=ms7019579240139182, createdTime=Wed Dec 23 08:19:00 CST 2015, time=2015-12-23, status=1, ipAttribution=)]
    2015-12-27 wzf990214

    有意思

    0

  7. 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href='/topic/show?id=cdfce8879b1' target=_blank style='color:#2F92EE;'>#绝经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78879, encryptionId=cdfce8879b1, topicName=绝经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Wed Dec 23 08:19:00 CST 2015, time=2015-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450442, encodeId=1d341450442b0, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Wed Dec 23 08:19:00 CST 2015, time=2015-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484071, encodeId=252914840e173, content=<a href='/topic/show?id=1a296e52078' target=_blank style='color:#2F92EE;'>#牙周疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67520, encryptionId=1a296e52078, topicName=牙周疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0c97946807, createdName=ms7019579240139182, createdTime=Wed Dec 23 08:19:00 CST 2015, time=2015-12-23, status=1, ipAttribution=)]
    2015-12-27 wzf990214

    赞一个

    0

  8. 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  9. 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