Clinical gastroenterology H: 微观结肠炎与胃肠道淋巴细胞疾病之间的关系

2018-11-24 MedSci MedSci原创

上消化道和下消化道的淋巴细胞紊乱似乎与胃肠道疾病存在显着关系。本文的目的是评估显微镜结肠炎(MC)患者合并淋巴细胞疾病的概率。

背景与目的
消化道和下消化道的淋巴细胞紊乱似乎与肠道疾病存在显着关系。本文的目的是评估显微镜结肠炎(MC)患者合并淋巴细胞疾病的概率。

方法
研究人员从2008年1月至2016年7月间回顾性分析了接受内窥镜检查的228506名患者中,研究发现有3456例MC患者存在乳糜泻,十二指肠上皮内淋巴细胞增多症,淋巴细胞性炎和淋巴细胞性食管炎的合并症。

结果
淋巴细胞紊乱发生在13.7%的MC患者以及5.9%的非MC患者中。MC患者淋巴细胞紊乱的OR:2.56(95%CI,2.32-2.82),任何类型的淋巴细胞疾病发生概率增高(OR:3.07;95%CI,1.25-7.52)淋巴细胞性食管炎(OR:15.05;95%CI,12.31- 18.41)。出现多种合并症在淋巴细胞性的结肠炎患者中更常见(OR:1.74,95%CI,1.42-2.13)。患有合并症的MC患者显着更年轻,腹泻是所有MC患者的主要症状。

结论
本项回顾性研究确定了上消化道淋巴细胞紊乱在患有MC的患者中明显更常见。这些关联表明存在一种潜在的病因,并会影响消化道疾病的发生。

原始出处:

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    2019-04-28 许安
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    2018-11-26 zll0628